Release of vasoactive intestinal peptide in canine septic shock

犬败血性休克中血管活性肠肽的释放

• 批准号: 61570618
• 负责人: HAYASAKA Hiroshi
• 金额: $ 1.15万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570618/
• 关键词: Vasoactive Intesinal Peptide (VIP); Septic shock; E.coli注入犬; Vasoactive Intestinal Peptide(VIP)

Vasoactive intestinal peptide (VIP), a potent vasodilator and hypotensive peptide, is present in high concentrations in the gut, a target organ in canine septic shock. We have tested the hypothesis VIP may be released into the circulation during septic shock in anesthetized dogs and may influence the pathogenesis and outcome of this disorder.The results suggest that (1) Plasma VIP levels increased markedly in all animals receiving E.coli, (2) the increase in plasma VIP concentrations was less pronounced in the group receiving MPSS/TOB infusions;(3) progressive decline in VIP concentration after the initial rise was associated with enhanced survial; and (4) MPSS/TOB therapy of shock induced by E.coli was more effective than TOB alone in improving survival.We conclude that circulating VIP levels increase during shock induced by E.coli in anesthetized dogs and that the VIP release may play a mediator-modulator role in the altered Physiology of septic shock.

血管活性肠肽 (VIP) 是一种有效的血管扩张剂和降血压肽，在肠道中以高浓度存在，而肠道是犬败血性休克的靶器官。我们已经测试了 VIP 可能在麻醉狗败血性休克期间释放到循环中的假设，并可能影响这种疾病的发病机制和结果。结果表明，(1) 在所有接受大肠杆菌的动物中，血浆 VIP 水平显着升高，(2) 在接受 MPSS/TOB 输注的组中，血浆 VIP 浓度的升高不太明显；(3) VIP 浓度在初始升高后逐渐下降 提高生存率； (4) MPSS/TOB 治疗大肠杆菌引起的休克在改善生存方面比单独使用 TOB 更有效。我们得出结论，在麻醉犬中大肠杆菌引起的休克期间，循环 VIP 水平增加，并且 VIP 释放可能在脓毒性休克生理学改变中发挥介质-调节剂作用。

项目成果

Kimiko Ishida;Hiroshi Hayasaka et.al: Journal of Surgical Research in Press.

Kimiko Ishida；Hiroshi Hayasaka 等：《外科研究杂志》出版。

Kimiko, Ishida; Hiroshi, Hayasaka, et. al.: "Plasma VIP concentration in canine septic shock." The Journal of the Japanese Association for Infections diseases. (1988)

石田公子；

Kimiko Ishida et al.: Canadian Journal of Physiology and Phomacology. 147-148 (1986)

Kimiko Ishida 等人：加拿大生理学和药物学杂志。