Release of vasoactive intestinal peptide in canine septic shock

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Vasoactive intestinal peptide (VIP), a potent vasodilator and hypotensive peptide, is present in high concentrations in the gut, a target organ in canine septic shock. We have tested the hypothesis VIP may be released into the circulation during septic shock in anesthetized dogs and may influence the pathogenesis and outcome of this disorder.The results suggest that (1) Plasma VIP levels increased markedly in all animals receiving E.coli, (2) the increase in plasma VIP concentrations was less pronounced in the group receiving MPSS/TOB infusions;(3) progressive decline in VIP concentration after the initial rise was associated with enhanced survial; and (4) MPSS/TOB therapy of shock induced by E.coli was more effective than TOB alone in improving survival.We conclude that circulating VIP levels increase during shock induced by E.coli in anesthetized dogs and that the VIP release may play a mediator-modulator role in the altered Physiology of septic shock.