Experimental Study on Circulatory Disturbance of Inner Ear Blood Flow

内耳血流循环障碍的实验研究

• 批准号: 61570821
• 负责人: TSUTOMU Nakashima
• 金额: $ 1.28万
• 依托单位: Nagoya University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570821/
• 关键词: Cochlear Blood Flow; Endocochlear Potential; 蝸牛血流; 気圧外傷; Microsphere; 蝸牛小管静脈

The effects of occlusion of the vein of the cochlear aqueduct were investigated using nonradioactive microspheres in guinea pigs. Upon the occlusion, the cochlear blood flow decreased to 50 - 80 % of the pre-occlusion level. When intracochlear hemorrhage occurred due to the occlusion, the cochlear blood flow decreased more significantly.The effects of round window membrane rupture on cochlear blood flow were also investigated. When inner ear pressures were raised artificially to relatively high levels, cochlear blood vessels were compressed and enocochlear potential decreased to negative values due to the interruption of cochlear blood flow. However, in the case when the round window membrane was ruptured by more increased inner ear pressures, the inner ear pressures decreased and restoration of cochlear blood flow and endo-cochlear potential was observed. When the round window membrane was ruptured with a fine needle under ordinary inner ear pressures, cochlear blood flow did not change significantly.

用非放射性微球对豚鼠耳蜗导水管静脉阻塞的影响进行了研究。阻断后，耳蜗血流量下降到阻断前水平的50 - 80%。当耳蜗闭塞导致内出血时，耳蜗血流量下降更为明显。研究了圆窗膜破裂对耳蜗血流的影响。当人为地将内耳压力升高到较高水平时，由于耳蜗血流中断，耳蜗血管受到压迫，耳蜗电位下降至负值。而当内耳压力增加，圆窗膜破裂时，内耳压力下降，耳蜗血流和耳蜗内电位恢复。在普通内耳压力下用细针穿刺破圆窗膜时，耳蜗血流无明显变化。

项目成果

渡辺祐介: Ear Reseach Japan. 34.

渡边佑介：日本耳朵研究 34。

Nakashima, T, Watanabe, Y, Kaida, M, and Yanagita, N.: "Effects of round window membrane rupture on cochlear blood flow and inner ear pressure" Acta Otolaryngologica (Stockholm).

Nakashima, T、Watanabe, Y、Kaida, M 和 Yanagita, N.：“圆窗膜破裂对耳蜗血流和内耳压力的影响”Acta Otolaryngologica（斯德哥尔摩）。

Nakashima, T, Watanabe, Y, and Yanagita, N.: "The effect of round window membrane rupture on endolymphatic and perilymphatic pressures" Archives of Otorhinolaryngology. 244. 236-240 (1987)

Nakashima, T、Watanabe, Y 和 Yanagita, N.：“圆窗膜破裂对内淋巴和外淋巴压力的影响”耳鼻喉科档案。