Role of tight junction (claudin) in the regulation of endocochlear potential

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It had been reported that mutatios in the gene encoding claudin-14 cause deafness and nephrolithiasis. In this experiment, we made the claudin-14 knockout mice to examine the functional role of tight junctions in the endolyphatic surface cells. The obtained experimental results were as follows; 1) endocochlear potential (EP) in the endolymph in knockout mice was lower than that in wild type mice. In the preset, we are trying to measure the H+, K+, Na+,Ca2+ concentrations in endolymph. All above experimental results will be published in the next year.