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腫瘍に対する放射線効果を修飾する未知因子の解明

阐明改变辐射对肿瘤影响的未知因素

基本信息

批准号：
62010005
负责人：
坂本澄彦
金额：
$ 11.33万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Cancer Research
财政年份：
1987
资助国家：
日本
起止时间：
1987 至无数据
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62010005/
关键词：
低線量全身照射マウス腫瘍転移ホルモン依存性腫瘍腫瘍免疫

项目摘要

放射線によって細胞死が起こるメカニズムは正確にはまだ十分に解明されていないと同様に, 放射線照射によって生体に生ずる種々の機能的変化のメカニズムも未知のものが非常に多いし, 種々の因子によって, 放射線の効果は修飾されることも知られている. 本研究では先ず, 今迄殆んど行なわれていなかった低線量全身照射の効果について検討した. 結果は, 低線量全身照射を担癌マウスに行なって, 6〜15時間後に腫瘍の局所照射を行なうと, 腫瘍の局所制御率が有意に上昇すること, 腫瘍細胞致死効果も有意に増加することが判った. この効果に近い効果は脾臓のみの照射によっても起こる所から, この効果が免疫系の関与によるものでないかと推定し, 腫瘍免疫学的検索を行なった. その結果は, 種々の腫瘍免疫検定法により, 低線量全身照射が担癌マウスの腫瘍免疫能を賦活化させる仂きをすることが証明され, 更にそれはマクロファージII分画が関与していることが示唆されている. この効果は臨床的に十分に応用可能と考えられる. すなわち, 低線量全身照射によって全身転移を抑え, 腫瘍の局所制御率を高めることが十分に予想される. 放射線治療においては, 腫瘍にのみ限局して放射線を与えることが出来れば, 腫瘍を根治するために十分な線量を与えればよいわけであるが, 実際は腫瘍周期の正常組織に対する照射は避けられず, そのため, 照射線量に自ら限界がでてくる. この至適線量が照射を受ける腫瘍や腫瘍が存在する部位によってどのように変るかを臨床データにともずいて検討し, 上顎癌及び子宮頸癌については至適線量の存在があることが判った. 又, 照射線量が多過ぎると微小転移が増加すること, その閾値は30Gyであることが動物実験の結果得られた. 又, 生体の腫瘍に対する防御反応を考えると, 現行の200ラド週5回法の治療法に種々の問題がある場合があることが示唆されている.

The radiation exposure is very important. It is very clear that the radiation is the same as that of radiation exposure. Radiation exposure is very sensitive to the production of several kinds of chemical energy. In this study, low dose whole body irradiation (WBI) has been successfully performed so far. The results showed that low dose whole body irradiation (WBI) was effective in the treatment of cancer, and after 6: 15, the rate of control was intentionally increased, and the effect of cell death was intentionally increased. The results show that the immune system and the immune system are closely related to the presumption and the immunological parameters of the immune system. The results showed that all kinds of immunoassays were performed, low dose whole body irradiation (WBI) was used to activate the immune response of cancer cells, and the results showed that there was no significant difference between the two groups. The results showed that low dose whole body irradiation (WBI) could activate the immune response of cancer cells, and further improve the performance of II. It is possible to test the size of the bed. Low-dose full-body irradiation, low-dose whole-body irradiation, low-dose full-body irradiation, low-dose whole-body irradiation, low-dose full-body irradiation, low-dose whole-body irradiation, low-dose whole-body irradiation, low-dose full-body irradiation, low-dose whole-body irradiation, low-dose whole-body irradiation, low-dose full-body irradiation, Radiation therapy, radiation therapy, radiation, radiation and radiation. From the dose of radiation to the dose of radiation, there is a dose of radiation in the area. There is a diagnosis of cancer in the upper body. In addition, the amount of radiation is much more than the small amount of radiation, and the effect of the dose is very small. In addition, the amount of radiation is much higher than that of the small amount of radiation, and the effect of the dose is very small. In addition, the amount of radiation is much higher than that of the small amount of radiation, and the effect of the dose is very small. In addition, the amount of radiation is much higher than that of the small amount of radiation, and the effect of the radiation dose is very small. In addition, the health care industry has conducted an examination on the prevention and treatment of various medical problems in the law, and has made an instigation to the health care department.