Oral Insulin Delivery facilitated by Enteric Coating using Dense Gas Technologies

使用致密气体技术通过肠溶衣促进口服胰岛素输送

• 批准号: LP0455701
• 负责人: Em/Prof Neil Foster
• 金额: $ 17.86万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-02-07 至 2008-08-07
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0455701
• 关键词: Oral; Insulin; Delivery; facilitated; Enteric

Insulin dependant diabetes is a rapidly growing disease. The current method for insulin delivery to the patient is by injection, which is inconvenient. Oral delivery of insulin is a more acceptable method. It is proposed to develop a dense gas technique to coat insulin with a pH sensitive polymer to protect it from the acidic environment of the stomach. Insulin can then be released at the high pH of the intestine when the polymer is dissolved. Particle size control is feasible by dense gas processes by manipulating operating parameters. Advantages include low residual solvent and manufacture at ambient temperatures.

胰岛素依赖型糖尿病是一种快速增长的疾病。目前向患者输送胰岛素的方法是注射，这很不方便。口服胰岛素是一种更容易接受的方法。建议开发一种致密气体技术，用 pH 敏感聚合物涂覆胰岛素，以保护其免受胃酸性环境的影响。当聚合物溶解时，胰岛素可以在肠道的高pH值下释放。通过操纵操作参数，通过浓密气体工艺可以实现粒度控制。优点包括低残留溶剂和在环境温度下制造。