Oral Insulin Delivery facilitated by Enteric Coating using Dense Gas Technologies

胰岛素依赖型糖尿病是一种快速增长的疾病。目前用于将胰岛素输送给患者的方法是通过注射，这是不方便的。口服胰岛素是一种更容易接受的方法。建议开发一种稠密气体技术，用pH敏感聚合物包覆胰岛素，以保护其免受胃的酸性环境的影响。然后，当聚合物溶解时，胰岛素可以在肠的高pH下释放。通过操作操作参数，稠密气体工艺的粒度控制是可行的。优点包括低残留溶剂和在环境温度下制造。

Insulin dependant diabetes is a rapidly growing disease. The current method for insulin delivery to the patient is by injection, which is inconvenient. Oral delivery of insulin is a more acceptable method. It is proposed to develop a dense gas technique to coat insulin with a pH sensitive polymer to protect it from the acidic environment of the stomach. Insulin can then be released at the high pH of the intestine when the polymer is dissolved. Particle size control is feasible by dense gas processes by manipulating operating parameters. Advantages include low residual solvent and manufacture at ambient temperatures.