Drug Delivery Devices : Hydrogels manufactured utilising Dense Gas Technologies

药物输送装置：利用致密气体技术制造的水凝胶

• 批准号: LP0455474
• 负责人: Em/Prof Neil Foster
• 金额: --
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-02-07 至 2008-08-07
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0455474
• 关键词: Drug; Delivery; Devices; Hydrogels; manufactured

Many drugs are rapidly eliminated from the human body, and would benefit from being released over a long period of time. In this study, formulations to deliver drugs will be developed, using hydrogels: highly cross-linked, water saturated polymers. The polymers to be investigated are based on ingredients suitable for ingestion. Hydrogels are in common use as external therapeutic devices, such as contact lenses or wound dressings. However, hydrogels are not commonly in use as ingested drug delivery devices due to problems with the existing technologies, such as toxicity of ingredients. These problems will be addressed in this study.

许多药物会迅速从人体内消除，并会因长期释放而受益。在这项研究中，将使用水凝胶（高度交联的水饱和聚合物）开发递送药物的制剂。待研究的聚合物基于适合摄入的成分。水凝胶通常用作外部治疗装置，例如隐形眼镜或伤口敷料。然而，由于现有技术存在问题，例如成分的毒性，水凝胶并不常用作摄入药物输送装置。这些问题将在本研究中得到解决。