Supercritical-microfluidics technology for targeted delivery to the colon

用于靶向递送至结肠的超临界微流体技术

• 批准号: DP210100265
• 负责人: Em/Prof Neil Foster
• 金额: $ 14.77万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-12-30 至 2024-12-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210100265
• 关键词: Supercritical; microfluidics; technology; targeted; delivery

This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour requirement, higher production rate and better quality control than conventional production methods. The new process will combine benefits from both supercritical fluid technology (green process) and microfluidics (high mass & heat transfer).

这项研究将开发纳米系统，以将药物输送到结肠。我们的纳米系统将允许临床使用的化疗药物组合在一个单一的剂型中。这将提高输送到结肠的效率，同时减少不必要的副作用。将开发一种新型的超临界微流体系统，以连续方式生产治疗性纳米载体，比传统的生产方法具有更低的劳动力需求，更高的生产率和更好的质量控制。新工艺将结合超临界流体技术（绿色工艺）和微流体技术（高质量和高传热）的优点。