Development of New Synthetic Methods via Multi-Metallic Organic Compounds

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1) The Lewis Acid Mediated Reaction of Carbamates with gamma-Oxygenated Allyltin and its Application to (<plus-minus>) -Statine Synthesis^1The Lewis acid mediated reaction of acyliminium ions (2) with gamma-oxygen substituted allyltin (1a) gives the amino alcohol derivatives (3) and (4) in good yields ; in certain cases very high diastereoselectivity is achieved and the procedure is applied to the synthesis of (<plus-minus>) -statin2) Regioselective Synthesis of either alpha- or gamma-Amino Acid Derivatives via Li, Sn-Masked, and/or Ge-Masked Dienolates^2Either the alpha- or gamma-amono acid derivatives can be prepared with very high regioselectivity by treating diethyl azodicarboxylate (DEAD) with (a) lithium dienolates themselves in certain cases, (b) Sn-masked dienolates, or (c) Ge-masked dienolates.3) Stereodivergent Synthesis of 1, 2-Diols via alpha-Methoxylead CompoundsThe reaction of alpha-methoxyleads with aldehydes gives either syn-1, 2-diols or antiisomers by merely changing the Lewis acids.