Clinical and Basic Research on Pulpal inflammation

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Pulpal inflammation is a commonly observed disease in dental clinics. The purpose of this research projects was functionally to investigate the basic mechanisms of the pulpal inflammation with special reference to the pain, which was an important and characteristic symptom of this disease. The conclusion of each study was as follows :1. The inferior alveolar nerve-driven neurons were identified in the upper cervical spinal cord (C2 or C3). Neck muscle inputs also converged onto these neurons.2. Branched nerve fibers existed in the trigeminal nerve innervating both the deciduous tooth pulp and the following permanent one.3. Epinephrind itself had the anesthetic effects on the deciduous tooth pulp nerve fibers, caused by the anoxia in the periapical tissue.4. The strong stimuli made the pulpal nerve fibers sensitized in the early stage of the pulpal inflammation, and the myelinated fibers at first increased their activities and later generated and decreased them. While the unmyelinated fibers kept their activities even in the late stage of the inflammation. These nerve activities were involved in the characteristic pulpal pain.5. Periodontal nerve fibers showed the modified activity due to the intracanal medicament after pulpal extirpation procedures.6. Potassium Oxalate solution did not have stimulative effects on the pulp tissue when applied to the exposed dentin, and showed significant effects to improve the dentin hypersensitivity in patients.7. The referred pain seemingly caused by the pulpal and/or periodontal diseases was statistically investigated in patients. A careful anesthetic test easily revealed the causative tooth.8. The infiltrating anesthesia applying both on the buccal and lingual side of the tooth was the most effective method for the extirpation of the lower molar tooth pulp.