Morphological and physiological studies of age-related changes in pulp and periodonata* tissues, and epidemiological study of atypical orofacial pai*.

牙髓和牙周*组织与年龄相关变化的形态学和生理学研究，以及非典型口面部的流行病学研究*。

• 批准号: 05404065
• 负责人: SUDA Hideaki
• 金额: $ 22.66万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05404065/
• 关键词: ageing; odontoblast; macrophage; plasma cell; microneurography; alkaline phosphatase; EMG activity; chemical stimulation; 象牙芽細胞; 免疫組織化学; シナプスの可塑的変化; 歯髄血流量; 歯髄処置; 歯髄・歯周組織の加齢的変化; 骨組織の破壊吸収; 生体防御能; Nd・YAGレーザー; 難治性疼痛患者; 歯髄処理

Age-related changes were as follows : 1) These existed some differences in rat jaw muscle EMG activity induced by mustard oil application to maxillary tooth pulps ; the less EMG activities were evoked and the latency of late phase EMG response was prolonged in 20-week-old rats ; 2) OX6+cells increased in number after the eruption of the tooth. In aged rats, the density of ED1+cells was maintained but a significant decrease in the density of OX6+cells was observed ; 3) Percentage of nerve fibers hydrodynamically activated decreased in elderly subjects. While evoked and spontaneous discharges were observed, old subjects sometimes did not perceive any sensations ; 4) In human tooth pulp, alkaline phosphatase activity decreased with increasing age but cell cycle did not change.

与年龄相关的变化如下： 1）上颌牙髓涂抹芥末油引起的大鼠颌肌肌电图活性存在一定差异； 20周龄大鼠肌电活动诱发较少，晚相肌电反应潜伏期延长； 2) 牙齿萌出后OX6+细胞数量增加。在老年大鼠中，ED1+细胞密度保持不变，但OX6+细胞密度显着下降； 3）老年受试者中流体动力激活的神经纤维百分比下降。虽然观察到诱发放电和自发放电，但老年受试者有时感觉不到任何感觉； 4）在人牙髓中，碱性磷酸酶活性随着年龄的增长而降低，但细胞周期没有改变。

项目成果

Ikeda, H.et al: "The lsolation of odontoblasts from cat teeth" J.Physiol. 476(P). 12-13 (1994)

Ikeda, H.等人：“从猫牙中分离成牙本质细胞”J.Physiol。

Suda et al.: "Procedigs of International Conference on Dentin/Pup Csnplex 1995 and the International Meeting on Clinical Topics of D/P Conpler" Quintessence Publishing Co., 377 (1996)

Suda 等人：“1995 年 Dentin/Pup Csnplex 国际会议论文集和 D/P Conpler 临床主题国际会议论文集”Quintessence Publishing Co.，377 (1996)

Okiji, T., Kosaka, T., Kamal, A.M.M., Kawashima, N., Suda, H.: "Age-Related Changes in the Immunoreactivity of the Monocyte Macrophage System in Rat Molar Pulp." Archs Oral Biol.41 (5). 453-460 (1996)

Okiji, T.、Kosaka, T.、Kamal, A.M.M.、Kawashima, N.、Suda, H.：“大鼠磨牙浆中单核巨噬细胞系统免疫反应性的年龄相关变化。”

Matti Narhi et al.: "The Neurophysiological Basis and the Role of Inflammafory Reactions in Dentive Hypersensitivity" Archs oral Biol.39(Suppl.). 23S-30S (1994)

Matti Narhi 等人：“神经生理学基础和炎症反应在牙本质过敏中的作用”Archsoral Biol.39（增刊）。

Takashi Okiji et al.: "Distribution of Ia Antigen-Expressing Nonlymphoid Cells in Various Stages of Induced Periapical Lesions in Rat Molars" Journal of Endodontics. 20. 27-31 (1994)

Takashi Okiji 等人：“大鼠磨牙诱发根尖周病变各个阶段表达 Ia 抗原的非淋巴细胞的分布”牙髓学杂志。