Analysis of marginal and apical periodontal diseases and their systemic effects

SUDA用免疫组织化学方法研究了实验性大鼠根尖周围病变的防御反应特征，并检测了中性粒细胞减少对病变发展的影响。田中发现，过氧化脂质参与了根尖周病变的发展。Kawanami用扫描电子显微镜观察到，根尖孔周围的外牙根表面有几种细菌。熊井对实验诱导的狗牙周内-牙周损伤进行了组织学研究。Yamaki证明，氢氧化钙作为根管内药物用于临床是有效的。Okamoto测量了牙周病细菌在脂多糖攻击后单核细胞释放的几种细胞因子。Ishikawa证实了黏附分子在牙周病变中的表达。J.Nakamura指出，拔牙合能促进根管充填后根尖周组织的愈合。OSSADA研究了培养的p…成纤维细胞的一些生物学特性更多的根尖肉芽肿。西川发现，测量牙周组织对牙齿撞击的脉冲响应可用于诊断牙周组织的疾病状况。H.Nakamura研究了根管内细菌内毒素对培养的牙髓细胞、牙周膜细胞和颅骨细胞的影响。木村透露，一些成人牙周炎患者在自体混合淋巴细胞反应中表现出较低的反应。吉川用免疫组织化学方法研究了巨噬细胞在大鼠根尖周肉芽肿中的分布。村山发现，牙周袋中黑色素厌氧菌的种群密度因地点而异，甚至在单个牙周袋中也存在DNA多态性。Matsuo分析了根尖周围病变中免疫活性细胞数量与受累牙齿临床表现之间的相关性。用原位杂交的方法证实了实验诱导的根尖周损伤中存在IL-1βmRNA表达的细胞。横田研究了交感神经对牙周组织的影响。较少

Suda investigated immunohistochemically the characteristics of defense reactions in experimentally-induced rat periapical lesion and examined the effects of neutropenia on the development of the lesion. Tanaka found the involvement of lipid peroxides in the development of periapical lesion. Kawanami observed using SEM that several bacteria were present at the outer root surface around the apical foramen. Kumagai investigated histologically the experimentally-induced endodontal-periodontal lesions in dogs. Yamaki showed that Ca(OH)_2 used as an intracanal medicament was effective for clinical use. Okamoto measured the release of several cytokines from monocytes after the challenge of LPS from periodontopathic bacteria. Ishikawa demonstrated the expression of adhesion molecules in periodontal lesions. J. Nakamura revealed that periapical tissue healing following root canal filling was stimulated by disocclusion. Osada investigated some biological properties of fibroblasts cultured from p … More eriapical granulomas. Nishikawa found that the measurement of impulse-response of periodontium to tooth percussion was applicable for the diagnosis of the diseased conditions of periodontium. H. Nakamura investigated the effects of LPS from intracanal bacteria on cultured pulpal cells, periodontal ligament cells and calvarial cells. Kimura revealed that some adult periodontitis patients showed lower responses in autologous mixed lymphocyte reaction. Yoshikawa investigated immunohistochemically the distribution of macrophages in rat periapical granulomas. Murayama found that the population density of black-pigmented anaerobic rods in periodontal pocket varied from site to site and that there was DNA polymorphism of P. gingivalis even in a single pocket. Matsuo analyzed the correlations between the number of immunocompetent cells in periapical lesions and the clinical findings of the involved teeth. Maeda demonstrated the presence of IL-1beta mRNA-expressing cells in experimentally-induced periapical lesion using in situ hybridization. Yokota investigated the effects of sympathetic nerves on the periodontal tissue. Less