Analysis of marginal and apical periodontal diseases and their systemic effects

Suda用免疫组织化学方法研究了实验性大鼠根尖周围病变的防御反应特征，并探讨了中性粒细胞减少对病变发展的影响。Tanaka发现脂质过氧化物参与了根尖周围病变的发展。Kawanami通过扫描电镜观察到，在根尖孔周围的外根表面存在几种细菌。Kumagai从组织学上研究了实验诱导的狗的牙髓-牙周病变。Yamaki表明，Ca(OH)_2作为内源性药物在临床上是有效的。Okamoto测量了牙周病细菌LPS攻击后单核细胞中几种细胞因子的释放。Ishikawa证实了黏附分子在牙周病变中的表达。J. Nakamura发现，牙合脱臼可以促进根管充填后的根尖周组织愈合。Osada研究了从p . More根尖肉芽肿培养成纤维细胞的一些生物学特性。Nishikawa发现测量牙周组织对牙齿撞击的脉冲响应可用于牙周组织病变的诊断。H. Nakamura研究了来自肛管内细菌的LPS对培养的牙髓细胞、牙周韧带细胞和头骨细胞的影响。木村发现一些成人牙周炎患者自体混合淋巴细胞反应较低。Yoshikawa用免疫组织化学方法研究了巨噬细胞在大鼠根尖周围肉芽肿中的分布。Murayama发现不同部位牙周袋黑色厌氧棒的种群密度不同，即使在单个牙周袋中也存在牙龈假单胞菌的DNA多态性。Matsuo分析了根尖周病变中免疫活性细胞的数量与相关牙齿的临床表现之间的相关性。Maeda通过原位杂交证实了il -1 β mrna表达细胞在实验诱导的根尖周围病变中的存在。横田研究了交感神经对牙周组织的影响。少

Suda investigated immunohistochemically the characteristics of defense reactions in experimentally-induced rat periapical lesion and examined the effects of neutropenia on the development of the lesion. Tanaka found the involvement of lipid peroxides in the development of periapical lesion. Kawanami observed using SEM that several bacteria were present at the outer root surface around the apical foramen. Kumagai investigated histologically the experimentally-induced endodontal-periodontal lesions in dogs. Yamaki showed that Ca(OH)_2 used as an intracanal medicament was effective for clinical use. Okamoto measured the release of several cytokines from monocytes after the challenge of LPS from periodontopathic bacteria. Ishikawa demonstrated the expression of adhesion molecules in periodontal lesions. J. Nakamura revealed that periapical tissue healing following root canal filling was stimulated by disocclusion. Osada investigated some biological properties of fibroblasts cultured from p … More eriapical granulomas. Nishikawa found that the measurement of impulse-response of periodontium to tooth percussion was applicable for the diagnosis of the diseased conditions of periodontium. H. Nakamura investigated the effects of LPS from intracanal bacteria on cultured pulpal cells, periodontal ligament cells and calvarial cells. Kimura revealed that some adult periodontitis patients showed lower responses in autologous mixed lymphocyte reaction. Yoshikawa investigated immunohistochemically the distribution of macrophages in rat periapical granulomas. Murayama found that the population density of black-pigmented anaerobic rods in periodontal pocket varied from site to site and that there was DNA polymorphism of P. gingivalis even in a single pocket. Matsuo analyzed the correlations between the number of immunocompetent cells in periapical lesions and the clinical findings of the involved teeth. Maeda demonstrated the presence of IL-1beta mRNA-expressing cells in experimentally-induced periapical lesion using in situ hybridization. Yokota investigated the effects of sympathetic nerves on the periodontal tissue. Less