Quantitative Epidemiological Study on Risk of Hepatocellular Carcinoma

肝细胞癌风险的定量流行病学研究

• 批准号: 63570265
• 负责人: FUKUDA Katsuhiro
• 金额: $ 1.34万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570265/
• 关键词: primary hepatocellular carcinoma; case-control study; hepatitis B surface antigen; blood transfusion; drinking habits; logistic regression model; multivariate analysis; 輸血歴; 喫煙歴; HBsAg

A total of 654 hepatocellular caricinoma patients were admitted to the Kurume University Hospital during 1988 and 1990. Of them, 191 cases fulfilled the eligible criteria such as primary hepatocellular cancer or age between 40 and 79 years old. One age (within 5 year age group)-, sex-, and residence-matched control was obtained from the inpatients of the two university affiliated general hospitals in Kurume city. Life-style information with the subjects were obtained by a trained interviewer and their medical records were reviewed by the author. By the end of 1990, 133 case-control pairs (male 110 ; female 23) were completed for data analysis. The 55-59 age group among male and the 60-64 among female predominated in number. Approximately 80% of the cases were histologically diagnosed and about 90% suffered from liver cirrhosis. Among the controls, the patients whose dIagnosis at the time of admission was cancer other than liver or peptic ulcer were predominant in number. The HBs antige … More n positive rates were 10% among male cases, 17% among female cases and 1 or 4% among male or female controls, respectively. The proportion of the subjects who had blood trasfusion more than 10 years prior to the time of interview were 19% among male cases, 26% among female cases and 7 or 4% among male or female controls. In order to quantify the amount of ethanol consumed, "One drink" was defined as a drink when a subject consumed any alcoholic beverage containing alcohol equivalent to 23 ml of ethanol and "drink-years" was defined as the number of drinks times the duration in year of the subject's drinking habit. Among males, 74% of cases and 60% of controls consumed alcohol of more than 1 drink-years by age 40 and the heavy drinkers who consumed alcohol more than 60 drink-years by age 40 wwre more prevalent among cases. The majority of females, either cases or controls, consumed alcohol of less than 1 drink-years by age 40. Multivariate analysis applied to these three factors simultaneously based on a logistic regression model revealed that HBs antigen positive, blood transfusion, and heavy drinking might be the independent risk factors for hepatocellular carcinoma. The odds ratios for males were 11.8, 3.0 and 5.6, respectively (P<0.05) but for females none was statistically significant. It was also statistically significant among males that the more the alcohol amount consumed by age 40, the higher the risk of development of hepatocellular carcinoma. Less

在1988年和1990年期间，共有654名肝细胞癌患者入住库尔斯克大学医院。其中，191例符合合格标准，如原发性肝细胞癌或年龄在40至79岁之间。一个年龄（5岁以内的年龄组），性别和居住地匹配的控制，从两个大学附属综合医院在Kurdahan市的住院患者。生活方式的信息与受试者获得了一个训练有素的采访者和他们的医疗记录由作者审查。截至1990年底，已完成病例对照对133对（男110对;女23对）进行数据分析。55-59岁年龄组的男性和60-64岁年龄组的女性人数最多。约80%的病例经组织学诊断，约90%患有肝硬化。在对照组中，入院时诊断为肝癌或消化性溃疡以外的癌症的患者占绝大多数。HBs抗原 ...更多信息 n阳性率男性为10%，女性为17%，男性和女性对照分别为1%和4%。在访谈前10年以上输血的受试者比例在男性病例中为19%，在女性病例中为26%，在男性或女性对照中为7%或4%。为了量化所消耗的乙醇量，“一杯饮料”定义为当受试者消耗含有相当于23 ml乙醇的酒精的任何酒精饮料时的饮料，并且“饮酒年”定义为饮酒次数乘以受试者饮酒习惯的年持续时间。在男性中，74%的病例和60%的对照组在40岁时饮酒超过1饮酒年，并且在40岁时饮酒超过60饮酒年的重度饮酒者在病例中更为普遍。大多数女性，无论是病例组还是对照组，到40岁时饮酒少于1饮酒年。多因素Logistic回归分析显示，HBsAg阳性、输血和大量饮酒可能是肝癌的独立危险因素。男性的优势比分别为11.8、3.0和5.6（P<0.05），而女性的优势比无统计学意义。在男性中，40岁之前饮酒量越多，患肝细胞癌的风险就越高，这一点在统计学上也很显著。少