Physiological roles of growth factors in mammalian reproduction.
生长因子在哺乳动物繁殖中的生理作用。
基本信息
- 批准号:63570771
- 负责人:
- 金额:$ 1.41万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1988
- 资助国家:日本
- 起止时间:1988 至 1990
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Physiological roles of growth factors especially epidermal growth factor (EGF) were studied in the field of mammalian reproduction and major findings are as follows :I. Establishment of pregnancy and fetal growth.Plasma EGF concentrations were elevated during pregnancy in human and there was positive correlation between maternal and fetal EGF levels although fetal levels were significantly lower than maternal ones.Sialoadenectomy (removal of the submandibular glands) of pregnant mice was shown to cause EGF deficiency during pregnancy which resulted in intrauterine growth retardation (IUGR). This makes an animal model to study the mechanism of fetal growth and IUGR.II. Maturation of oocyte and spermatozoa.EGFlike substance (EGF-L) was present in the human follicular fluid obtained from patients in our in vitro fertilization program. The concentration of EGF-L was related with the maturity of oocyte within. EGF-L was also present in human seminal fluid and concerned with sperm morbidity.EGF stimulated the maturation of rat oocyte in culture in terms of both germinal vesicle breakdown (resumption of meiosis) and phosphofructokinase activity (rate-limiting enzyme present in the cytoplasma).III. Development of preimplantation embryo.Presence and number of EGF receptor was determined using binding assay with I-125 EGF. Presence of EGF receptor was demonstrated in mouse oocyte and the number of EGF receptor was increased as embryos developed in preimplantation period. EGF added to the culture medium stimulated the development of 2-cell embryos.
生长因子尤其是表皮生长因子(EGF)在哺乳动物生殖过程中的生理作用已被广泛研究。妊娠的建立和胎儿的生长。人类妊娠期间血浆EGF浓度升高,母体和胎儿EGF水平之间存在正相关,尽管胎儿EGF水平显著低于母体。妊娠小鼠的涎腺切除术(切除下颌下腺)被证明会导致妊娠期间EGF缺乏,从而导致宫内生长迟缓(IUGR)。这为研究胎儿生长发育和IUGR机制提供了一种动物模型。卵母细胞和精子的成熟:在我们的体外受精程序中,从患者的卵泡液中获得了EGF样物质(EGF-L)。EGF-L的浓度与卵母细胞的成熟度有关。人精液中也含有EGF-L,与精子的发病率有关。EGF刺激培养的大鼠卵母细胞的成熟,包括成熟囊泡破裂(减数分裂的恢复)和磷酸果糖激酶活性(细胞质中存在的限速酶)。植入前胚胎的发育:用I-125 EGF结合试验测定EGF受体的存在和数量。EGF受体在小鼠卵母细胞中存在,并随胚胎发育而增加。培养基中添加EGF可刺激2细胞胚胎的发育。
项目成果
期刊论文数量(34)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Masahiko Mizuno: "Role of prostaglandins in egg implantation." Advances in gynecological endocrinology Parthenon Publishing Group. 1. 433-439 (1989)
水野正彦:“前列腺素在卵子着床中的作用。”
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O. Tsutsumi: "A physiological function of epidermal growth factor in spermatogenesis and oocyte maturation." Japan Journal of Fertilization and Implantation. 6. 19 (1989)
O. Tsutsumi:“表皮生长因子在精子发生和卵母细胞成熟中的生理功能。”
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堤治: "Epidermal growth factor(EGF)と妊娠・胎児発育" 臨床婦人科産科. 43. 247-251 (1989)
Osamu Tsutsumi:“表皮生长因子 (EGF) 与妊娠和胎儿发育”《临床妇产科》43. 247-251 (1989)。
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堤 治: "卵胞の発育成熟とepjidermal growth factor(EGF)" 産婦人科の世界. 41. 367-373 (1989)
Osamu Tsutsumi:“卵泡发育和成熟与表皮生长因子 (EGF)”《妇产科世界》41. 367-373 (1989)。
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堤治: "Epidermal growth factor(EGF)と性機能" ホルモンと臨床. 37. 205-209 (1989)
Osamu Tsutsumi:“表皮生长因子 (EGF) 和性功能”激素和临床研究 37. 205-209 (1989)。
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TSUTSUMI Osamu其他文献
TSUTSUMI Osamu的其他文献
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{{ truncateString('TSUTSUMI Osamu', 18)}}的其他基金
White-color luminescence from a single material with harmony between order- and disorder-structures of luminogen aggregates
单一材料的白色发光,发光体聚集体的有序结构和无序结构之间的协调
- 批准号:
15K05613 - 财政年份:2015
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Self-organization of gold nanoparticles and photochemical manipulation of their organized structures by means of liquid-crystalline molecules
金纳米粒子的自组织及其通过液晶分子对其组织结构进行光化学操纵
- 批准号:
21710094 - 财政年份:2009
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Development of Photoresponsive Organic-Inorganic Hybrid Liquid Crystals : Spontaneous Organization of Inorganic Nanoparticles with Organic Molecules
光响应有机-无机杂化液晶的开发:无机纳米粒子与有机分子的自发组织
- 批准号:
19559003 - 财政年份:2007
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A laboratory and clinical study of the mechanism of mother-to-child infection of Toxoplasma
弓形虫母婴感染机制的实验室及临床研究
- 批准号:
15591732 - 财政年份:2003
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
STUDIES ON FACTORS RELATED TO EMBRYO DEVELOPMENT TO IMPROVE OUTCOME OF ASSITED REPRODUCTIVE TECHNOLOGY
研究胚胎发育相关因素以提高辅助生殖技术的效果
- 批准号:
12671580 - 财政年份:2000
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
BASIC STUDIES FOR IMPROVEMENT OF IN VITRO FERTILIZATION AND CRYOPRESERVATION
改进体外受精和冷冻保存的基础研究
- 批准号:
10671518 - 财政年份:1998
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analysis of the microenvironment and cryopreservation of embryos on their development
胚胎发育的微环境和冷冻保存分析
- 批准号:
08671870 - 财政年份:1996
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Assessmemt of embryo viability and its microenvironment
胚胎活力及其微环境的评估
- 批准号:
06671632 - 财政年份:1994
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Biochemical and endocrinological analysis of oocytes and embryos
卵母细胞和胚胎的生化和内分泌分析
- 批准号:
03670771 - 财政年份:1991
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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