The Influence of the Fear Induced Procedure on the Concentration of Brain Catecholamines.

恐惧诱发程序对脑儿茶酚胺浓度的影响。

基本信息

  • 批准号:
    63570934
  • 负责人:
  • 金额:
    $ 1.41万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 财政年份:
    1988
  • 资助国家:
    日本
  • 起止时间:
    1988 至 1990
  • 项目状态:
    已结题

项目摘要

Effects of stimulation of the hypothalamus that is thought to control emotional and behavioral patterns, eg fear, on the trigemino-autonomic reflex were studied in chloralose-anesthetized cats. The exact place of stimulation was the hypothalamic defense area, stimulation of which induced aggressive responses called defense reaction, such as mydriasis, increased blood pressure and tachycardia. The reflex discharges were recorded from the cervical vagel nerve, and the cardiac branch of the vagal nerve in response to electrical stimulation of the inferior alveolar nerve. The discharge in the cardiac branch of the vagal nerve evoked by the inferior alveolar nerve stimulation was completely abolished by transection of the cervical spinal cord, while it was not affected by section of the cervical vagal nerve. Thus the trigemino-autonomic reflex in the cardiac branch of the vagal nerve wholly consisted of the sympathetic nerve discharge (trigemino-sympathetic reflex), in contrast to that recorded form the cervical vagal nerve(trigemino-vagal reflex). The following results were obtained.1) The trigemino-vagal reflex was depressed by repetitive stimulation of the hypothalamic defense area. The threshold was below that for inducing cardiovascular changes. Short train pulse applied to the hypothalamic defense area suppressed the trigemino-vagal reflex for about 200ms with a peak at about 40ms. It is suggested that the hypothalamic effect on the trigemino-vagal reflex was centrally induced and not the secondary effect of cardiovascular changes.2) The trigemino-sympathetic reflex showed no definite changes in response to repetitive stimulation of the hypethalamic defense area.These results support the notion that the trigemino-autonomic reflex is centrally intergraded to suit the cardiovascular system to the needs of the organism in defense reaction.
被认为控制情绪和行为模式(如恐惧)的下丘脑的刺激对三叉神经自主反射的影响在氯氯麻醉的猫中进行了研究。刺激的确切位置是下丘脑防御区,刺激该区域会引起被称为防御反应的攻击性反应,如流泪、血压升高和心动过速。记录了颈迷走神经和迷走神经心支对下肺泡神经电刺激的反射放电。下肺泡神经刺激引起的迷走神经心支放电被颈脊髓横断完全消除,而不受颈迷走神经横断的影响。因此,迷走神经心脏分支的三叉-自主神经反射完全由交感神经放电(三叉-交感反射)组成,与颈迷走神经(三叉-迷走反射)记录的情况相反。得到了以下结果:1)反复刺激下丘脑防御区可抑制三叉神经迷走反射。该阈值低于诱发心血管变化的阈值。下丘脑防御区施加短列脉冲抑制三叉迷走反射约200ms,在40ms左右达到峰值。提示下丘脑对三叉神经迷走神经反射的影响是中枢诱导的,而不是心血管变化的继发效应。2)反复刺激下丘脑防御区,三叉神经交感反射无明显变化。这些结果支持了三叉神经-自主神经反射集中整合以适应心血管系统对机体防御反应的需要的观点。

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
深山治久: 日本歯科麻酔学会雑誌. 12. 450-458 (1984)
Haruhisa Miyama:日本牙科麻醉学会杂志 12. 450-458 (1984)。
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    0
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嶋田晶彦: "笑気および電気刺激の内因性モルヒネ様物質に及ぼす影響" 日本歯科麻酔学会雑誌. 11. 441-449 (1983)
Akihiko Shimada:“笑气和电刺激对内源性吗啡样物质的影响”日本牙科麻醉学会杂志 11. 441-449 (1983)。
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    0
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小長谷 光: "三叉・自律神経反射に対する視床下部防衛領域刺激の効果" 日本歯科麻酔学会雑誌. 19. 38-50 (1991)
Hikaru Konagae:“下丘脑防御区刺激对三叉神经自主反射的影响”日本牙科麻醉学会杂志 19. 38-50 (1991)。
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    0
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Katakura, Nobuo: "Effects of Stimulation of Hypothalamic Defense Area on Trigemino-autonomic Reflex in Cats" J. Jap. Dent. Soc. Anesthesiol.19-1. 38-50 (1991)
Katakura,Nobuo:“刺激下丘脑防御区对猫三叉神经自主反射的影响”J. Jap。
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  • 影响因子:
    0
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小長谷 光: "三叉・自律神経反射に対する視床下部防衛領域刺激の効果" 日本歯科麻酔学会雑誌. 19. 38-58 (1991)
Hikaru Konagae:“下丘脑防御区刺激对三叉神经自主反射的影响”日本牙科麻醉学会杂志 19. 38-58 (1991)。
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KATAKURA Nobuo其他文献

KATAKURA Nobuo的其他文献

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{{ truncateString('KATAKURA Nobuo', 18)}}的其他基金

Analysis of neural mechanisms of transformation from sucking to mastication in in vitro brain preparations.
体外脑制剂中从吸吮到咀嚼转变的神经机制分析。
  • 批准号:
    11671837
  • 财政年份:
    1999
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analysis of neural mechanisms of rhythm generation for sucking -induction of optical imaging method in in vitro preparations obtained from newborn mice.
光学成像方法分析新生小鼠体外制剂吸吮诱导节律产生的神经机制。
  • 批准号:
    10557162
  • 财政年份:
    1998
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Neural mechanisms of rhythm generation for mastication-analysis in an in vitro brain preparation from abult mammals
用于咀嚼分析的节律产生的神经机制在离体哺乳动物的体外大脑制备中
  • 批准号:
    09671887
  • 财政年份:
    1997
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Ion channel analysis of neurons of the mesencephalic trigeminal nucleus in in vitro preparations
体外制剂中中脑三叉神经元的离子通道分析
  • 批准号:
    06671850
  • 财政年份:
    1994
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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Analysis of adverse effects of acetylcholinergic pesticides focused on the induction of host defense reaction and immune disruption
乙酰胆碱能农药不良反应分析重点关注诱导宿主防御反应和免疫破坏
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利用植物逆境防御反应生产高附加值蔬菜的环境控制方法的开发
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    25292150
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    2013
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磷脂信号在水稻防御反应和种子成熟中的作用
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    16570043
  • 财政年份:
    2004
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Exchange of signal molecules derived from fungal parasites and plants on the plant surfaces and then-signal transmission leading to defense reaction or accessibility induction.
来自真菌寄生虫和植物的信号分子在植物表面进行交换,然后信号传输导致防御反应或可及性诱导。
  • 批准号:
    12052219
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Research on the mechanisms involved in pathogenicity and induction of defense reaction by plant pathogenic bacteria.
植物病原菌致病及诱导防御反应机制的研究。
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    12052210
  • 财政年份:
    2000
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    $ 1.41万
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Chemical elucidation for the mechanism of the defense reaction of plant cells
化学阐明植物细胞防御反应机制
  • 批准号:
    09480142
  • 财政年份:
    1997
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    $ 1.41万
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Regulation of host defense reaction gy parasitoid
寄生蜂对宿主防御反应的调节
  • 批准号:
    04660046
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CORONARY CONSTRICTION IN THE DEFENSE REACTION
防御反应中的冠状动脉收缩
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    3051781
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    1992
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    $ 1.41万
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CORONARY CONSTRICTION IN THE DEFENSE REACTION
防御反应中的冠状动脉收缩
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    3051780
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Cellular Defense Reaction in Biomphalaria Glabrata: Ultrastructural Studies
光滑双脐动物的细胞防御反应:超微结构研究
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