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The Constituents of Gasteromycetes

腹菌纲的成分

基本信息

批准号：
63570994
负责人：
TAKAISHI Yoshihisa
金额：
$ 1.54万
依托单位：
The University of Tokushima
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

Traditional medicine and its science have a long history. People are very experienced in using fungi as medicine. Fungi which were recognized as the important components of traditional herbal drugs in ancient times like Poria cocos, Polyporus umbellatus, Treamella fuciformis etc. Have still been used extensively up to the present in China and Japan, while new fungus medicines are being discovered continually.But the taxonomy of higher fungi is behind than that of plants, the collection of higher fuguses is very difficult in the field, the yield of extracts from fuguses is very low than that of plants. So the studies of constituents of higher fuguses are behind than that of plants.We have been an interest about the constituents of higher fuguses by reason of above mention. Especially, Gasteromycetes are unique higher fungi because they have a gleba in the sexless peridium. The constituents of Gasteromycetes are only known about Lycoperdon pyriforme, L. parlatum, Calvatia cramiformi and … More Pisolithus tinctorius. We have been studying about the constituents of Gasteromycetes. We could obtain the following results in this research project.1) Astraeus hygrometricus is used in Chinese folk medicine and has been used as a haemastatic. Three new lanostane triterpenes, as well as two known steroids, were isolated from A. hygronetricus. The new compounds were established by chemical and spectroscopic means.2) Two new triterpenes were isolated from Pisolithus tinctoricus and these structures were established by spectroscopic means.3) Lasiosphaera nipponica is used in Japanese and Chinese folk medicine as a haemastatic. New polyoxyg enated ergosterol derivative, as well as three known steroids were isolated from this fungi. The structure of the new steroid was established by chemical and spectoroscopic means.4) Three new aromatic compounds, as well as three known steroids, two known aromatic compounds were isolated from calvatia ramiformis. The structures of these compounds were established by chemical and spectroscopic means. The new aromatic compounds have a unique structures in the natural compounds. Less

传统医学及其科学有着悠久的历史。人们在使用真菌作为药物方面非常有经验。真菌是古代传统草药的重要组成部分，如茯苓、猪苓、银耳等，至今在中国和日本仍被广泛使用，新的真菌药物也不断被发现，但高等真菌的分类学落后于植物，野外采集高等真菌十分困难，真菌提取物的产率比植物提取物的产率低得多。因此，对高等真菌化学成分的研究相对于植物化学成分的研究相对滞后，因此，对高等真菌化学成分的研究引起了人们的极大兴趣。特别是腹菌纲是一种独特的高等真菌，因为它们在无性别的包被中有一个囊。腹菌纲的成分仅知于梨形马勃（Lycoperdon pyriforme）、L. parlatum，马勃， ...更多信息彩色豆石我们一直在研究腹菌纲的化学成分。本课题主要研究结果如下：1）黄芪是我国民间常用的止血药。从A.水栖的2）从豆石（Pisolithus tinctoricus）中分离得到两个新的三萜类化合物，并通过波谱方法确定其结构; 3）日本和中国民间常用的止血药日本马勃（Lasiosphaera nipponica）。从该真菌中分离得到新的麦角甾醇衍生物和三种已知的甾体化合物。4）从枝状马勃中分离得到3个新的芳香族化合物，以及3个已知的甾族化合物和2个已知的芳香族化合物。这些化合物的结构通过化学和光谱手段确定。这些新的芳香族化合物在天然化合物中具有独特的结构。少