Development of Novel Sensors Using Macrocyclic Polyamines as Sensory Elements

使用大环多胺作为传感元件的新型传感器的开发

• 批准号: 63840019
• 负责人: UMEZAWA Yoshio
• 金额: $ 7.1万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B).
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63840019/
• 关键词: Macrocyclic Polyamine; Anion-selective Electrode; Adenosine Nucleotide; Dicarboxylic Acid; Potentiometry; Langmuir-Blodgett (LB) Membrane Sensor; Permeability Change; Cyclic Voltammetry; 脂溶性大環状ポリアミン; 分子認識素子; ATP^<4->センサ-; ジカルボン酸陰イオンセンサ-; ボルタンメ

A novel type of chemical sensors were constructed by using macrocyclic polyamines and related compounds as sensory elements. Potentiometric responses and selectivities were investigated and the following results were obtained, demonstrating a remarkable potentiality of this class of hosts as novel sensory elements.(1) The macrocyclic polyamine liquid membrane electrodes showed strong potentiometric responses and marked selectivities for organic anions such as adenosine nucleotides and dicarboxylates. Potentiometric selectivities based on the magnitude of charge or the distance between charges within the guest molecule were observed.(2) These electrodes also showed potentiometric responses to catechol and related compounds that are in the nonionic forms at the experimental pH. A systematic investigation demonstrated proton ejection as a possible mechanism for potentiometric responses to the uncharged molecules.(3) Sapphyrin (expanded porphyrin) and cytosine-pendant triamine were examined as novel sensory elements for anion-selective liquid membrane electrodes.(4) Anion responsive Langmuir-Blodgett (LB) membrane sensors were fabricated with polyamine hosts. Selectivities for organic anions were evaluated on the basis of analyte-induced permeability changes detected by cyclic voltammetry.

以大环多胺及其相关化合物为传感元件，构建了一种新型的化学传感器。研究了电位反应和选择性，得到了以下结果，证明了这类寄主作为新型感觉元件的显着潜力。(1)大环多胺液膜电极对腺苷核苷酸和二羧酸盐等有机阴离子具有较强的电位响应和明显的选择性。根据电荷的大小或客体分子内电荷之间的距离观察到电位选择性。(2)在实验ph值下，这些电极对儿茶酚和非离子形式的相关化合物也显示出电位响应。系统的研究表明，质子喷射可能是对不带电分子电位响应的一种机制。(3)研究了Sapphyrin （expanded porphyrin）和cytosine- pendal triamine作为阴离子选择性液膜电极的新型感觉元件。(4)以多胺为载体制备负离子响应式Langmuir-Blodgett （LB）膜传感器。通过循环伏安法检测分析物诱导的渗透性变化来评价有机阴离子的选择性。

项目成果

S.Nagase: "Voltammetric Anion Responsive Sensors Based on Modulation of Ion Permeability through Langmuir-Blodgett Films Containing Synthetic Anion Receptors" Anal.Chem.(1990)

S.Nagase：“基于通过含有合成阴离子受体的 Langmuir-Blodgett 薄膜调节离子渗透性的伏安阴离子响应传感器”Anal.Chem.(1990)

Y.Umezawa: "Ion-Selective Electrodes 5" Akademiai Kiado and Elsevier, (1989)

Y.Umezawa：“离子选择电极 5”Akademiai Kiado 和 Elsevier，(1989)

Y.Umezawa(編著): "CRC Handbook of IonーSelective Electrodes:Selectivity Coefficients" CRC Press, 848 (1990)

Y. Umezawa（编辑）：《CRC 离子选择性电极手册：选择性系数》CRC Press，848 (1990)

M. KATAOKA, R. NAGANAWA, K. ODASHIMA, Y. UMEZAWA, E. KIMURA AND T. KOIKE: "Potentiometric liquid membrane sensors that discriminate linear homologs and geometrical/positional isomers of dicarboxylates" ANAL. LETT.22. 1089-1105 (1989)

M. KATAOKA、R. NAGANAWA、K. ODASHIMA、Y. UMEZAWA、E. KIMURA 和 T. KOIKE：“区分二羧酸盐的线性同系物和几何/位置异构体的电位液膜传感器” ANAL。

M.Kataoka: Anal,Lett. (1989)

M.Kataoka：肛门，Lett。