Mechanism of Ethanol Degradation and Production in Intestinal Tract

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In this study, the intestinal tract contents in rabbit were examined bacteriologically in vitro and in vivo to clarify the mechanism of ethanol metabolism in it.1. In vivo study, it was demonstrated that ethanol was degraded and produced in the contents of cecum, colon and rectum.2. Alcohol dehydrogenase participated in the ethanol degradation in cecum content. Catalase had little effect on the degradation.3. These enzymes were created by enteric bacteria, and affected by chloramphenicol and colistin in vivo.4. The ethanol degradation in cecum content accounted for 3.5% of all ethanol degradation in vivo.5. In vitro study, enteric bacteria was demonstrated to degrade and produce the ethanol.6. The ethanol degradation of enteric bacteria (E. Coli) in vitro was mediated by alcohol dehydrogenase and catalase.The enteric bacteria that had a ability to degrade the ethanol was inhibited to multiply by chloramphenicol, streptomycin and colistin. It was suggested that the decrease of ethanol degradation by these antibiotics was the result of the inhibition to multiply the enteric bacteria.