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Brain Imaging Studies in Schizophrenia and Atypical Psychosis

精神分裂症和非典型精神病的脑成像研究

基本信息

批准号：
01570618
负责人：
OHARA M.
金额：
$ 1.02万
依托单位：
Aichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570618/
关键词：
Schizophrenia Atypical psychosis CT scan CT density IMP-SPECT Multivariate analysis ^<123>I-IMP SPECT

项目摘要

The brain morphological and/or functional differences between typical schizophrenia and atypical psychosis (ATP) were identified by means of brain imaging techniques.On CT scan studies, schizophrenics had significant enlargement of interhemispheric fissure, lateral and 3rd ventricle, and sylvian fissures (SF), while ATP patients had only significantly enlarged SFs, especially on the right side. Furthermore, a certain group of schizophrenics showed significantly higher density in the frontal regions and the head of caudate nucleus in contrast to ATP patients. On early image by ^<123>I-IMP SPECT, the schizophrenics showed significantly decreased uptake rates in the bilateral frontal regions, whereas, the ATP patients did so in the right basal ganglia. On late image, the schizophrenics displayed significantly decreased uptake rate not only in frontal region, but also in left occipital and basal ganglia regions. On the contrary, the ATP patients had no findings in any region.By cluster analysis of brain CT data, typical schizophrenia ATP tend to be grouped differently. The two groups with either interhemispheric fissure or left SF enlargement consisted mainly of schizophrenics. Another group, which had right SF enlargement and demonstrated more frequent family histories, comprised mainly ATP patients and paranoid-type schizophrenics. In fact, a considerable number of patients had no significant abnormal CT findings, suggesting that both psychoses are still heterogeneous and that further subclassification is warranted.As for ATP, our data indicate that a group of ATP patients with family histories might have functional disorders in right basal ganglia, and frequent recurrence might eventually result in right SF enlargement.

本文应用脑影像学技术，对典型精神分裂症与非典型精神病（ATP）的脑形态和/或功能进行了比较，结果表明：在CT扫描上，精神分裂症患者纵裂、侧脑室、第三脑室和侧裂（SF）明显增大，而ATP患者仅SF明显增大，尤其是右侧。此外，与ATP患者相比，精神分裂症患者的额区和尾状核头部的密度显著增高。在~（131）I-IMP SPECT早期显像上<123>，精神分裂症患者双侧额叶的摄取率明显降低，而ATP患者右侧基底节的摄取率明显降低。在晚像上，精神分裂症患者不仅额叶摄取率明显降低，而且左侧枕叶和基底节区摄取率也明显降低。对脑CT资料进行聚类分析，发现典型精神分裂症ATP有不同的分组倾向。纵裂或左侧SF增大者以精神分裂症患者为主。另一组，其中有右侧SF扩大，并表现出更频繁的家族史，主要包括ATP患者和偏执型精神分裂症。事实上，相当多的患者没有显着的异常CT表现，这表明这两种精神病仍然是异质性的，进一步的细分是warranted.As ATP，我们的数据表明，一组ATP患者的家族史可能有功能障碍，在右侧基底节，频繁复发可能最终导致右侧SF扩大。