Cerebrospinal fluid and blood circulation in subependymal tissue in hydrocephalus- Effect of cerebrospinal fluid diversion

脑积水的脑脊液与室管膜下组织的血液循环-脑脊液分流术的作用

• 批准号: 01570821
• 负责人: SATO Osamu
• 金额: $ 1.41万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570821/
• 关键词: hydrocephalus; periventricular tissue; cerebrospinal fluid; tissue water content; electronmicroscopy; ventriculo-pleural shunt; craniectomy

Results :Before shunt was put in water content in the subependymal tissue immediate underneath the ependymal cells was 72.2+__-l. 0 % and much increased than the water content of deep white matter tissue of 67.2 +__- 0.7 % The results indicate that water content is definitely increased just underneath the ventricular surface but increased than the water content of deep white matter tissue of 67.2+__-0.7 %. In the animals in which shunt did work, its water content in the subependymal tissue was 70.9+__-1.1% and this was not different from the control animals. In animals which failed to function after shunting water content did not decreased as might be expected and interestingly enough its water content in the deeper tissue was increased. Electron microscopic examination, however, did not show marked enlargement of the extracellular space in the deep white matter and also derangement of the axons and myelin fibers were not prominent at all.From the series of our experiment it was learned that if shunt procedure failed to reduce the ventricular size water content in the deep white matter, when say that it is only 2 or 3 mm from the ependymal surface though increased definitely suggesting an important role of the subependymal tissue as a subsidiary way of cerebrospinal fluid circulation.

结果：置管前室管膜下组织内紧邻室管膜细胞下方的含水量为72.2+_ - 1。结果表明，脑室表面下的含水量明显增加，但明显高于脑深部白质的含水量（67.2+__- 0.7%）。在分流术起作用的动物中，其室管膜下组织的含水量为70.9+_ -1.1%，与对照动物没有区别。在分流后失去功能的动物中，水分含量并没有像预期的那样减少，有趣的是，深层组织中的水分含量增加了。电镜检查未见深部白质胞外间隙明显增大，轴突和髓鞘纤维也未见明显紊乱。从我们的一系列实验中我们了解到，如果分流术未能减少脑室大小，当它距离室管膜表面只有2或3mm时，深部白质的含水量虽然增加，但肯定表明室管膜下组织作为脑脊液循环的辅助途径的重要作用。

项目成果

Takei F, Shapiro K, Kohn I: "Influence of the rate of ventricular enlargement on the white matter water content in progressive feline hydrocephalus." J Neurosurg. 66. 577-583 (1987)

Takei F、Shapiro K、Kohn I：“脑室扩大率对进行性猫脑积水白质含水量的影响。”

Bering EA Jr, Sato O: "Hydrocephaus : Changes information and absorption of cerebrospinal fluid within the cerebral ventricles." J Neurosurg. 20. 1050-1063 (1963)

Bering EA Jr、Sato O：“Hydrocephaus：改变脑室内脑脊液的信息和吸收。”

Clark RG, Milhorat TH: "Experimental hydrocephalus. Part III. Light microscopic findings in acute and subacute obstructive hydrocephalus in the monkey." J Neurosurg. 32. 400-413 (1970)

Clark RG、Milhorat TH：“实验性脑积水。第三部分。猴子急性和亚急性阻塞性脑积水的光学显微镜检查结果。”

Shapiro K, Takei F, Fried A, Kohn I: "Experimental feline hydrocephalus." J Neurosurg. 63. 82-87 (1985)

Shapiro K、Takei F、Fried A、Kohn I：“实验性猫脑积水。”

Shapiro K, Takei F, Fried A, Kohn I: "Hydrocephalic edema : Accessory CSF absorption or passive response to ventricular enlargement. Intracranial Pressure VI Miller JD, Teasdale GM, Rowan JO, Galbraith SL, Mendelow AD (Eds.)" Springer Verlag, Berlin Heide

Shapiro K、Takei F、Fried A、Kohn I：“脑积水水肿：附属脑脊液吸收或对脑室扩大的被动反应。颅内压 VI Miller JD、Teasdale GM、Rowan JO、Galbraith SL、Mendelow AD（编辑）” Springer Verlag