Biologically Active Compounds from a Philippine Medicinal Plant, Genus Premna

在对菲律宾药用植物臭豆腐柴布兰科的研究过程中，分离出两种单酰基和四种二酰基6-O-α-L-吡喃鼠李糖基梓醇。在菲律宾，这种植物用于松动痰，作为咳嗽治疗，促进排尿和阴道冲洗，以及心脏问题。一种近缘植物，P. japonica Miq.在中国也被用作退烧药、止血药和毒蛇咬伤的解毒剂。从日本梧桐叶中分离得到9个新的6-0-α-L-吡喃鼠李糖梓醇酰化衍生物。其结构经<13>~ 1H NMR、~ 1C NMR等物理化学方法确定。在冲绳采集到另一种相关植物，伞房蕨。这种植物在形态上更像P. odorata而不是P. japonica。这种植物的化学研究正在进行中，但毛蕊花糖苷的鸢尾苷结合物与毛蕊花糖苷和酰化6-O-alpha-L-rhamnopyuranosylcatalpol沿着分离出来。共轭结构测定的研究正在进行中。

In the course of investigation of the Phillipine medicinal plant, Premna odorata Blanco, two monoacyl and four diacyl 6-O-alpha-L-rhamnopyranosylcatalpols were isolated. In the Philippines, this plant is used for loosening phlegm, as a cough remedy, to promote urination and vaginalirrigation, and for cardiac troubles. A related plant, P. japonica Miq. is also used in China as an antipyretic, a hemostatic and an antidote for bites by poisonous snakes. From leaves of P. japonica, a total of nine new acylated deivatives of 6-0-alpha-L-rhamnopyranosylcatalpol was isolated. Their structures were determined by ^<13>C and ^1H NMR, and other physico-chemical meathods. Another related plant, P. corymbosa was collected in Okinawa. This plant morphologically resembles more with P. odorata than P. japonica. Chemical investigation of this plant is on the way, but irigoid glucoside conjugate of acteoside was isolated along with acteoside and acylted 6-O-alpha-L-rhamnopyuranosylcatalpol. Research on the structure determination of the conjugated is in progress.