Biologically Active Compounds from a Philippine Medicinal Plant, Genus Premna

来自菲律宾药用植物 Premna 属的生物活性化合物

• 批准号: 01571154
• 负责人: OTSUKA Hideaki
• 金额: $ 1.34万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01571154/
• 关键词: Premna odorata; Premna japonica; Verbenaceae; Iridoid; Rhamnopyranosylcatalpol; Monoacylrhamnopyranosylcatalpol; Diacylrhamnopyranosylcatalpol; Premna corymbosa; Verbenaceae; monoacylrhamnopyranosylcatalpol; discylrhamnopyranosylcatalpol

In the course of investigation of the Phillipine medicinal plant, Premna odorata Blanco, two monoacyl and four diacyl 6-O-alpha-L-rhamnopyranosylcatalpols were isolated. In the Philippines, this plant is used for loosening phlegm, as a cough remedy, to promote urination and vaginalirrigation, and for cardiac troubles. A related plant, P. japonica Miq. is also used in China as an antipyretic, a hemostatic and an antidote for bites by poisonous snakes. From leaves of P. japonica, a total of nine new acylated deivatives of 6-0-alpha-L-rhamnopyranosylcatalpol was isolated. Their structures were determined by ^<13>C and ^1H NMR, and other physico-chemical meathods. Another related plant, P. corymbosa was collected in Okinawa. This plant morphologically resembles more with P. odorata than P. japonica. Chemical investigation of this plant is on the way, but irigoid glucoside conjugate of acteoside was isolated along with acteoside and acylted 6-O-alpha-L-rhamnopyuranosylcatalpol. Research on the structure determination of the conjugated is in progress.

在对菲律宾药用植物臭豆腐柴布兰科的研究过程中，分离出两种单酰基和四种二酰基6-O-α-L-吡喃鼠李糖基梓醇。在菲律宾，这种植物用于松动痰，作为咳嗽治疗，促进排尿和阴道冲洗，以及心脏问题。一种近缘植物，P. japonica Miq.在中国也被用作退烧药、止血药和毒蛇咬伤的解毒剂。从日本梧桐叶中分离得到9个新的6-0-α-L-吡喃鼠李糖梓醇酰化衍生物。其结构经<13>~ 1H NMR、~ 1C NMR等物理化学方法确定。在冲绳采集到另一种相关植物，伞房蕨。这种植物在形态上更像P. odorata而不是P. japonica。这种植物的化学研究正在进行中，但毛蕊花糖苷的鸢尾苷结合物与毛蕊花糖苷和酰化6-O-alpha-L-rhamnopyuranosylcatalpol沿着分离出来。共轭结构测定的研究正在进行中。

项目成果

Hideaki Otsuka: "Premnosides AーD:diacyl 6ー0ーαーLーrhamnopyranosylーcatalpols from Premna odorata" Phytochemistry. 28. 3063-3067 (1989)

Hideaki Otsuka：“Premnosides A-D：来自 Premna odorata 的二酰基 6-0-α-L-rhamnopyranosy-catalpols” 植物化学 28. 3063-3067 (1989)。

Hideaki Otsuka: "Isolation and characterization of new diacyl 6ー0ーαーLーrhamnopyranosylcatalpols from the leaves of Premna japonica Miq." Chem.Pharm.Bull.38. 426-429 (1990)

Hideaki Otsuka：“从 Premna japonica Miq 叶中分离和表征新的二酰基 6－0－α－L－rhamnopyranosylcatalpols。”Chem.Pharm.Bull.38（1990）。

Hideaki Otsuka et al.: "Iridoid diglycoside monoacyl esters from the leaves of Premna japonica" J. Nat. Prod.53(01). 107-111 (1990)

Hideaki Otsuka 等人：“来自 Premna japonica 叶子的环烯醚萜二糖苷单酰酯”J. Nat。

Hideaki Otsuka: "6ー0ーαーLー(2"ー0ーand 3"ー0ーisoferuloyl)rhamnopyranosylcatalpols from Premna japonica" Phytochemistry. 28. 3069-3071 (1989)

Hideaki Otsuka：“来自 Premna japonica 的 6－0－α－L－（2”－0－和 3”－0－异阿魏酰）鼠李糖基梓醇”植物化学 28. 3069-3071 (1989)。

Hideaki Otsuka: "Iridoid diglycoside monoacyl esters from the leaves of Premna japonica" J.Nat.Prod.53. (1990)

Hideaki Otsuka：“来自 Premna japonica 叶子的环烯醚萜二糖苷单酰酯”J.Nat.Prod.53。