Biologically Active Compounds from a Philippine Medicinal Plant, Genus Premna

在对菲律宾药用植物百里香的研究过程中，分离到2个单酰基和4个双酰基6-O-α-L-鼠李糖基过氧化氢酶。在菲律宾，这种植物被用来化痰，作为止咳药，促进排尿和阴道冲洗，并用于心脏疾病。另一种近缘植物--日本大叶黄连。在中国中也被用作解热、止血和被毒蛇咬伤的解毒剂。从竹叶中分离得到9个新的酰化衍生物6-0-α-L-鼠李糖基梓醇。其结构经核磁共振氢谱、核磁共振氢谱等理化方法确证。另一种近缘植物--伞房锦鸡儿，也在冲绳采集到。这种植物在形态上更类似于P.odorata而不是P.Japan onica。对该植物的化学成分研究正在进行中，但从其化学成分中分离得到了刺梨糖苷结合物和乙酰化的6-O-α-L-鼠李糖基梓醇。共轭化合物的结构测定研究正在进行中。

In the course of investigation of the Phillipine medicinal plant, Premna odorata Blanco, two monoacyl and four diacyl 6-O-alpha-L-rhamnopyranosylcatalpols were isolated. In the Philippines, this plant is used for loosening phlegm, as a cough remedy, to promote urination and vaginalirrigation, and for cardiac troubles. A related plant, P. japonica Miq. is also used in China as an antipyretic, a hemostatic and an antidote for bites by poisonous snakes. From leaves of P. japonica, a total of nine new acylated deivatives of 6-0-alpha-L-rhamnopyranosylcatalpol was isolated. Their structures were determined by ^<13>C and ^1H NMR, and other physico-chemical meathods. Another related plant, P. corymbosa was collected in Okinawa. This plant morphologically resembles more with P. odorata than P. japonica. Chemical investigation of this plant is on the way, but irigoid glucoside conjugate of acteoside was isolated along with acteoside and acylted 6-O-alpha-L-rhamnopyuranosylcatalpol. Research on the structure determination of the conjugated is in progress.