Bioactive natural products which support Okinawan traditional cultures for food stuffs and medicines

支持冲绳传统食品和药品文化的生物活性天然产品

• 批准号: 13672216
• 负责人: OTSUKA Hideaki
• 金额: $ 2.3万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672216/
• 关键词: Anti histaminic; Megastigmane; Euphorbiaceae; Terpene; Glochidion zeylanicum; Myrisine seguinii; Cresipidia lanceolatum; メガスティグマン; 抗ヒスタミン遊離活性; ジテルペン; イリドイド; 抗アレルギー; セスキテルペン

Continuing works on Okinawan resource plants, constituents in Glochidion zeylanicum were investigated. Several flavonol glycosides were isolated and their structures were elucidated by spectroscopic analysis. From Myrisine seguinii, several megastigmane glucosidses were isolated along with a considerable amount of arbutin. Content of arbutin is fairy high and the plant expected to be a good source of arbutin, used for cosmetics.From Cresipidia lanceolatum, sequiterpene glucosides, which have an exo methylene functional group, were isolated. The exo methylene is known to have bactericidal activity and young leaves are used as an additive, when people eat raw fish. It is interesting that its actual usage and biological activity of its constituents showed good coincidence.Using Rat leukemia cells, RBL-2H3, anti-histaminic activity was assayed. Considering that, five or six plants were collectable in one mission, it must be good time for random screening of crude extracts. Plants belonging to Verbenaceae and Euphorbiaceae showed promising activity and awaiting to be investigated active compounds.

对冲绳的资源植物-锡兰算盘子的化学成分进行了研究。分离得到几个黄酮醇苷类化合物，并通过波谱分析鉴定了它们的结构。从Myrisine seguinii中分离出几种巨替格曼葡萄糖苷，其中沿着大量的熊果苷。该植物中熊果苷含量较高，有望成为化妆品中熊果苷的良好来源。已知外切亚甲基具有杀菌活性，嫩叶被用作添加剂，当人们吃生鱼时。用大鼠白血病细胞RBL-2H_3测定其抗组胺活性。考虑到在一次使命中可采集到五六种植物，这一定是随机筛选粗提物的好时机。马鞭草科和大戟科植物具有很好的活性，有待进一步研究。

项目成果

H.Otsuka et al.: "Stereochemistry of megastigmane glucosides from Glochidion zeylaricum and Alangium premnifolium"Phytochemistry. 62.5. 763-768 (2003)

H.Otsuka 等：“Glochidion zeylaricum 和 Alangium premnifolium 中巨豆豆苷的立体化学”植物化学。

Y.Takeda, H.Shimidzu, K.Mizuno, S.Inouchi, T.Masuida, E.Hirata, T.Shinzato, M.Aramoto, H.Otsuka: "An iridoid glucoside dimer and a non-glycosidic iridoid from the leaves of Lasianthus wallachii"Chemical and Pharmaceutical Bulletin. 50(10). 1395-1397 (2002

Y.Takeda、H.Shimidzu、K.Mizuno、S.Inouchi、T.Masuida、E.Hirata、T.Shinzato、M.Aramoto、H.Otsuka：“来自叶子的环烯醚萜苷二聚体和非糖苷环烯醚萜苷

H.Otsuka, H.Kijima, E.Hirata, T.Shinzato, A.Takushi, M.Bando, Y.Takeda: "Glochidionionosides A-D : Magastigmane glucosides from leaves of Glochidion zeylanicum (Gaertn) A.Juss"Chemical and Pharmaceutical Bulletin. 51(03). 286-290 (2003)

H.Otsuka、H.Kijima、E.Hirata、T.Shinzato、A.Takushi、M.Bando、Y.Takeda：“Glochidioninosides A-D：Glochidion zeylanicum (Gaertn) A.Juss 叶子中的 Magastigmane 糖苷”化学和药物通报

D.H.He et al.: "Tricalysiosides A-G; Rearranged ent-kauraene glycosides from the leaves of Tricalysia dubia"J. Natural Products. 64・5. 685-688 (2002)

D.H.He 等人：“Tricalysiosides A-G；来自 Tricalysia dubia 叶子的重排对映贝壳杉烯糖苷”J. Natural Products 64・5 (2002)。

H.Otsuka et al.: "Glochiflavanosides A-D : Flavanol glucosides from the leaves of glochidion zeylanicum (Gaerten) A. Juss"Chem. Pharm. Bull.. 49・07. 921-923 (2001)

H. Otsuka 等人：“Glochiflavanosides A-D：来自 glochidion zeylanicum (Gaerten) A. Juss 叶子的黄烷醇葡萄糖苷”，Pharm. Bull. 921-923 (2001)。