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Effective use of resource plants growing in subtropical and tropical areas, Okinawa and southeast Asia, respectively

有效利用亚热带和热带地区、冲绳和东南亚分别生长的资源植物

基本信息

批准号：
18590117
负责人：
OTSUKA Hideaki
金额：
$ 2.47万
依托单位：
Hiroshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590117/
关键词：
natural product resource plant active compound Okinawa southeast Asia

项目摘要

Chemical constituents of Macaranga tanarius, Bridelia glauca f. balansae, Tricalysia dubia, Helicia cochinsinensis, Euodia meliaefolia, collected in Okinawa were investigated. From B. glauca f. balansae and E. meliaefolia, many megastigmane glycosides were isolated. Their structures were elucidated by means of NMR spectroscopy and absolute structure was substantiated by the modified Mosher's method. From branches of Tricalysia dubia, several rearranged diterpenoids and other known compounds were isolated. MTT assay using KB cells revealed that stigmasterol showed strong activity. Multi drug resistance assay was performed using K563/Adr and several rearranged diterpenoids showed the strong activity. Following plants originated from Thailand were, investigated: Acanthus volubilis, Dolichandrone serrulata, Morinda elliptica, Erythroxylon cuneatum, Equisetum debile, E. diffusum, Spermacoce laevis, Leea thorelli, Dioecrescis erythroclada, Strophiblachia fimbricalyx, Oldenladia corymbosa. From these plants, phenolic glycosides, megastigmane glycoside and so on were isolated. Biological investigations of these plant products are in progress.From Scoparia dulcis, Curcuma aff. aeruginosa, originated from Vietnam, diterpenoids and sesquiterpenoids were isolated, respectively.

对产自冲绳的黄芩、青花菊、杜鹃、胭脂垂花、细叶垂花的化学成分进行了研究。从青花莲和黑叶莲中分离出了大量的大芪甲苷。用核磁共振光谱对其结构进行了表征，并用改进的Mosher法对其绝对结构进行了确证。从杜鹃的分支中分离出了几种重排二萜和其他已知化合物。KB细胞MTT试验显示，豆甾醇具有较强的活性。用K563/Adr进行多药耐药试验，多个重排二萜具有较强的耐药活性。研究了下列原产于泰国的植物：毛囊棘、细木犀、椭圆Morinda、凸红杉、细木犀、白花棘、细木犀、细木犀、细木犀、细木犀、细木犀、细木犀、细木犀、细木犀、细木犀、细木犀、细木犀、细木犀。从这些植物中分离出酚类苷、大葛地甘苷等。这些植物产品的生物学研究正在进行中。从越南产的铜绿姜黄（Curcuma affer . aeruginosa）和杜鹃花（Scoparia dulcis）中分别分离到二萜和倍半萜。