Computational Fluid Mechanical Study of the Effects of the Blood Flow in Atherogenesis

动脉粥样硬化中血流影响的计算流体力学研究

• 批准号: 01571243
• 负责人: YAMAGUCHI Takami
• 金额: $ 1.22万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01571243/
• 关键词: Atherosclerosis; Hemodynamic Factor; Wall Shear Stress; Computational Fluid Mechanics Model; Supercomputer

Results of a numerical model study of the flow field and the wall shear stress distribution patterns in the vicinity of early atherosclerotic plaques were examined using a computational fluid mechanics method. It was shown from the computation that unsteadiness significantly affected the wall shear stress distribution in the neighborhood of minimal deformations of the arterial wall particularly under unsteady flow conditions. It was also shown that upstream condition did not severely influence the downstream flow structure. In other words, local flow structure was mainly determined by the local geometry. Complexity of flow field invoked by the irregularity of vascular walls was stressed and the necessity of fluid mechanical studies of the blood flow under three dimensional unsteady flow conditions was pointed out. The computational fluid dynamical method incorporating supercomputers was shown to be very useful to understand the fine structure of those flow fields.

使用计算流体力学方法研究了早期动脉粥样硬化斑块附近的流场和壁面剪切应力分布模式的数值模型研究结果。计算结果表明，非定常性对动脉壁最小变形附近的壁面剪应力分布有显著影响，特别是在非定常流动条件下。研究还表明，上游条件并没有严重影响下游的流动结构。换句话说，局部流动结构主要由局部几何形状决定。强调了血管壁的不规则性所引起的流场的复杂性，指出了三维非定常流动条件下血液流动的流体力学研究的必要性。结合超级计算机的计算流体动力学方法被证明是非常有用的，以了解这些流场的精细结构。

项目成果

山口隆美、花井荘太郎: "血流モデルによる血管病変発生機構の研究ー電気化学的方法による壁ずり応力測定と三次元数値流体力学モデルの対比ー" 脈管学. 30.

Takami Yamaguchi、Sotaro Hanai：“使用血流模型研究血管病变发展的机制 - 使用电化学方法和三维计算流体动力学模型测量壁剪切应力的比较”Angiology 30。

山口隆美,花井荘太郎: "血流モデルによる血管病変発生機構の研究ー電気化学的方法による壁ずり応力測定と三次元数値流体力学モデルの対比ー" 脈管学. 30.

Takami Yamaguchi，Sotaro Hanai：“使用血流模型研究血管病变发展的机制 - 使用电化学方法和三维计算流体动力学模型测量壁剪切应力的比较”Angiology 30。

T.Yamaguchi, S.Hanai: "Effects of Blood Flow on Atherogenesis - A Study Using Electrochemical Shear Stress Measurements and Computational Fluid Mechanics -" J.Jpn.Coll.Angiol Vol.30, 1990.

T.Yamaguchi、S.Hanai：“血流对动脉粥样硬化的影响 - 使用电化学剪切应力测量和计算流体力学的研究 -”J.Jpn.Coll.Angiol Vol.30，1990。

T.Yamaguchi,A.Nakano,S.Hanai: "Bio-Mechanical Transport Processes" Plenum Press, (1990)

T.Yamaguchi、A.Nakano、S.Hanai：“生物机械运输过程”Plenum Press，（1990）

T.Yamaguchi, A.Nakano, S.Hanai: "Three dimensional shear stress distribution around small atherosclerotic plaques with steady and unsteady flow." Bio-Mechanical Transport Processes. (eds) F.Mosora, C.G.Caro, C.Baquey, H.Schmid-Schonbein, R.Pelissier, E.Kr

T.Yamaguchi、A.Nakano、S.Hanai：“稳定和不稳定流动的小动脉粥样硬化斑块周围的三维剪切应力分布。”