Mechanism of the formation, destruction, and movement of thrombi responsible for ischemia of vital organs

导致重要器官缺血的血栓形成、破坏和运动的机制

• 批准号: 16200031
• 负责人: YAMAGUCHI Takami
• 金额: $ 28.12万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16200031/
• 关键词: Biomechanics; Medical Engineering; Blood Flow; Thrombosis; Platelet; Red Blood Cell; Cardiovascular System; Simulation; 生物・生体工学; 粒子法; マイクロPIV; 血球; 構造流体連成

We investigated multi-scale behaviors of the formation, destruction, and movement of thrombi under blood flow that are responsible for ischemia of vital organs by using computer simulation and in vitro experiments based on biomechanics. We carried out computer simulations based on a Stokesian Dynamics method and a particle method to characterize the relationships between physiological and fluid mechanical factors in platelet aggregation under blood flow. We determined the relationships between deformation of red blood cells and apparent blood flow resistance. The result indicated that interactions among blood cells play a pivotal role in blood flow properties. It was also shown that biological/mechanical interactions among different types of blood cells determine thrombogenesis process. We established an in vitro quantitative measurement of blood flow through micro channel with micro PIV system, and obtained a spatiotemporal velocity fluctuation in blood flow that depends on hemaetocrit values. This indicated that mechanical interaction among blood cells governs blood flow properties. We proposed a large-scale computer simulation model of flow of red blood cells with the Earth Simulator, and established mathematical formulae of blood flow that can explain hierarchical mechanical behaviors of blood flows from the scale of blood cells (jam) to large vessel (cm). We also developed an integrated computer model of the left ventricle and the aorta, and demonstrated that the model is practically useful in detailed evaluation of the vortex and stagnation, which greatly affects thrombogenesis, in heart and large arteries.

以生物力学为基础，通过计算机模拟和体外实验，研究了导致重要器官缺血的血栓在血流作用下的形成、破坏和运动的多尺度行为。我们基于Stokesian动力学方法和粒子方法进行了计算机模拟，以表征血液流动下血小板聚集过程中生理因素和流体力学因素之间的关系。我们确定了红细胞变形和表观血流阻力之间的关系。结果表明，血细胞之间的相互作用在血液流动特性中起着关键作用。研究还表明，不同类型血细胞之间的生物/机械相互作用决定了血栓形成过程。利用Micro PIV系统建立了微通道血流的体外定量测量系统，得到了血流速度随红细胞压积变化的时空变化规律。这表明血细胞之间的机械相互作用控制着血液流动特性。利用地球模拟器建立了红细胞流动的大规模计算机模拟模型，建立了血液流动的数学公式，可以解释血液流动从血细胞尺度(JAM)到大血管(CM)的分层力学行为。我们还开发了一个完整的左心室和主动脉的计算机模型，并证明了该模型在详细评估心脏和大动脉中对血栓形成有很大影响的涡旋和停滞是有用的。

项目成果

Quantitative Measurements on the Human Ascending Aortic Flow Using 2D Cine Phase-Contrast Magnetic Resonance Imaging

使用二维电影相衬磁共振成像对人体升主动脉流量进行定量测量

• 发表时间: 2005
• 期刊: JSME International Journal, Series C 48・4
• 作者: M. Kawanishi;A. Ohura;K.S. Furukawa;T. Fukubayashi;K. Nakamura;T. Tateisi;and T. Ushida;S.Yokosawa et al.
• 通讯作者: S.Yokosawa et al.

心臓・血管系の臨床医療を支援する生体力学シミュレーションシステム

支持心脏和血管系统临床医疗的生物力学模拟系统。

• 发表时间: 2006
• 期刊: 血管医学 7・1
• 作者: 山口;荒船;佐久間;寺澤;柴田;本荘;児玉;神谷;山口隆美
• 通讯作者: 山口隆美

Study on Particle Presentations of Blood Cells and the Plasma in Microvascular Blood Flow, In : Biomechanics at Micro- and Nanoscale Levels

微血管血流中血细胞和血浆颗粒呈现的研究，见：微米和纳米级生物力学

• 发表时间: 2006
• 作者: Tokuda;S.;et. al.;K.Nishida et al.;T.Yamaguchi et al.
• 通讯作者: T.Yamaguchi et al.

Simulation Study on Effects of Deformabilities on Blood Flow Using Particle Method

变形能力对血流影响的粒子法模拟研究

• 发表时间: 2006
• 期刊: Transactions of the JSME, Series B(in Japanese) Vol.72, No.718
• 作者: Nakamura;Ka.;Yamashita;Y.;Tamamaki;N.;Katoh;H.;Kaneko;T.;Negishi;M;K.Tsubota et al.
• 通讯作者: K.Tsubota et al.

Effect of Flow Disturbances Remaining at the Beginning of Diastole on Intraventricular Diastolic Flow and Colour M-mode Doppler Echocardiograms

舒张初期残留的血流扰动对心室内舒张血流和彩色 M 型多普勒超声心动图的影响

• 发表时间: 2004
• 期刊: Medical and Biological Engineering and Computing 42・4
• 作者: Makimoto;N. and Sakata;H.;M.Nakamura et al.
• 通讯作者: M.Nakamura et al.