权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Study on Mechanisms of the Development of Cardiovascular and Cerebrovascular Diseases

心脑血管疾病发生发展机制的研究

基本信息

批准号：
15086204
负责人：
YAMAGUCHI Takami
金额：
$ 20.48万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2006
项目状态：
已结题

项目摘要

Human cardiovascular system is always under the integrated nervous and Humoral control of the whole body, i.e., in homeostasis. Multiple feedback mechanisms with mutual interactions among systems, organs, and even tissues provide integrated control of the entire body. These control mechanisms have different spatial coverage, from the micro- to macroscale, and different time constants, from nanoseconds to decades. Based on this consideration, we investigated the cardiovascular system over micro to macro levels by using conjugated computational mechanics analyzing fluid and solid interactions in the research project. We studied blood flow in the aorta with beating left ventricle as a power source, ATP transport in a cerebral artery with aneurysm, the progress of cerebral aneurysm due to adaptation of arterial wall, the blood flow considering more than 16 thousands of red blood cells' motion, and platelets aggregation in blood flow using a particle method developed for the purpose.The aortic blood flow showed independence from the intraventricular vortices formation downstream from the aortic arch, where the three dimensional configuration of the aorta determined the global flow structure. Transport and distribution of ATP molecule was found to be strongly dependent on the relative position of aneurysms to the mother arteries. The particle method developed in the present study showed its potential to represent the microscale aggregation process of the platelet in the blood flow.In considering clinical applications, however, one needs to include more about biological complexities in the analysis of blood flow, especially with respect to disease processes. A disease is not just a failure of machine. It is an outcome of complex interactions among multi-layered systems and subsystems. We expect that biological phenomena, including disease processes, will be clarified in the future by integrating new understandings of macroscale and microscale hemodynamics.

人体心血管系统始终处于全身神经和体液的综合控制之下，即，体内平衡系统、器官甚至组织之间相互作用的多重反馈机制提供了对整个身体的综合控制。这些控制机制具有不同的空间覆盖范围，从微观到宏观尺度，以及不同的时间常数，从纳秒到几十年。基于这一考虑，我们在本研究项目中通过共轭计算力学分析流体和固体的相互作用，从微观到宏观层次研究了心血管系统。我们研究了以左心室搏动为动力源的主动脉血流，动脉瘤脑动脉ATP转运，动脉壁适应性脑动脉瘤的进展，考虑了超过16000个红细胞运动的血流，用颗粒法测定了主动脉血流和血小板聚集，主动脉血流与心室内血流无关，在主动脉弓下游形成涡流，其中主动脉的三维构型决定了整体流动结构。ATP分子的转运和分布强烈依赖于动脉瘤与母动脉的相对位置。在本研究中开发的粒子方法显示了其潜力，代表微尺度的血小板聚集过程中的血流，然而，在考虑临床应用，需要包括更多的生物学复杂性的血流分析，特别是相对于疾病的过程。疾病不仅仅是机器的故障。它是多层次系统和子系统之间复杂相互作用的结果。我们期望，生物现象，包括疾病过程，将在未来澄清的宏观和微观尺度血流动力学的新认识。