Trace Analysis for Drugs and Poisons in Human Tissues

兴奋剂药物分析：用Extremut柱提取技术代替传统的溶剂提取方法。CO-Hb分析：测定全血CO-Hb浓度随贮存时间和温度的变化。挥发物的分析：对包括醇类在内的挥发物的气相色谱分析条件进行了修订，特别是对柱条件进行了修订。采用毛细管柱，灵敏度高，峰分离度好。安眠药分析：研究了血液中巴比妥类药物的最佳测定条件。采用Sep-pak C18柱、毛细管柱和氮磷检测器的气相色谱联用，可有效地分离和测定局麻药中的氮磷。 ...更多信息 研究了在气相色谱仪上检查药物的定量分析。农药分析：为了建立一种灵敏、选择性好的方法，采用气相色谱/质谱联用技术对有机磷、氯代物和氟代物3种农药进行了分析。百草枯的分析：灵敏度，回收率，所需的时间和成本进行了检查与采样和前处理程序。二次差示分光光度法在实际中是有用的。生物组织中锑的测定：采用石墨原子化无火焰原子吸收光谱法，对生物组织中锑进行了分析。免疫分析方法的改进：从药物和激素的一般性方面对免疫分析方法进行了考察。利用特异性抗体，观察药物、激素等抗原在机体组织中的动态。毒理分析中的干扰物质：对毒理分析时的干扰物质进行研究，以便从分析数据中获得可靠的信息。本文从法医毒理学的实际出发，对上述10个主题进行了研究，取得了有意义的结果。少

Analysis of stimulant drugs : A conventional solvent extraction method was replaced by an extraction technique using Extrelut column. The technical procedure was simplified and the accuracy of measurement was improved.Analysis of CO-Hb : The changes in CO-Hb concentration in the whole blood in storage was examined with regard to the lapse of time and temperature. Useful information could be obtained from practical aspects.Analysis of volatiles : Analytical conditions of gas chromatography were revised on volatiles including alcohols, especially as to the column condition. Good results were obtained in sensitivity and peak separation, by the use of capillary column.Analysis of hypnotics : The optimum conditions for detecting barbiturates in the blood were examined. The combination of Sep-pak C18 column, capillary column in gas chromatography using nitrogen phosphorus detector was found preferable.Analysis of local anesthetics : Mass spectrometry of various kinds of local anesthetics was … More studied. Quantitative analysis of the drugs was examined on gas chromatography. Good results were obtained when a surface ionization detector was used.Analysis of insecticides : In order to establish a sensitive and selective method, gas chromatography/mass spectrometry was applied to 3 types of insecticides including organic phosphorus, chlorinated and fluorine compounds. Good results were obtained in the detection limits, calibration, and repeatability.Analysis of paraquat : Sensitivity, recovery, required time and costs were examined in connection with sampling and procedure of pre-treatment. A secondary differential spectrophotometry was found useful in practice.Determination of antimony In biological tissues : Using a flameless atomic absorption spectrometer with graphite atomizer, antimony in biological tissues was analyzed. The time for analysis was reduced and sensitivity was improved.Improvement of lmmunoassay : Immunoassay method was examined from general aspects on drugs and hormones. Using special antibody, the dynamics of such antigens as drugs and hormones in the body tissues were observed.Interfering substances in toxicological analysis : Interfering substances at the time of toxicooogical analysis were studied in order to obtain reliable information from analytical data. Exact identification was found possible by using gas chromatography/mass spectrometry.The study was made on the above 10 theme from the practical aspects of forensic toxicology, and meaningful results could be obtained. Less