Membrane Structures for Bio-communication

我们研究了膜上生物通讯的分子机制。首先，我们研究了荧光显微镜的新方法。Nakanishi博士研究了共聚焦荧光显微镜，并研究了免疫反应中的钙信号。他发现，受体介导的钙信号不仅被转移到细胞质，还被转移到细胞核。Kinosita博士研究了一种双视角显微镜，Kusumi博士研究了一种荧光寿命成像显微镜。通过这些方法，他们研究了膜表面的生物通讯。北川博士用荧光法研究了血小板膜流动性，发现了膜流动性的不对称性。葛西纪明和基里诺对离子通道进行了研究，他们发现了离子通道在生物交流中的作用。稻垣博士和远藤博士确定了在膜生物通讯中起作用的蛋白质的结构。Hatta博士和Mitaku博士提出了蛋白质和脂类动态结构的新模型，这些模型调节了膜上的生物通讯。根据这些结果，我们展示了膜上生物通讯动力学的新图景。

We have studied the molecular mechanisms of bio-communication on the membrane. First, we investigated new methods for fluorescence microscopes. Dr. Nakanishi investigated a confocal fluorescence microscope and studied the calcium signals in the immune responses. He found that the receptormediated calcium signals were transferred not only to the cytoplasm but also to the nucleus. Dr. Kinosita investigated a dual-view microscope and Dr. Kusumi investigated a fluorescence life-time imaging microscope. By thses methods they studied bio-communications on the membrane surfaces. Dr. Kitagawa studied platelet membrane fluidity by fluorescence method and found asymmetry of membrane fluidities. Dr. Kasai and Dr. Kirino studied ion channels and they discovered roles of ion channels in bio-communications. Dr. Inagaki and Dr. Endo determined the structures of proteins which work in membrane bio-communications. Dr. Hatta and Dr. Mitaku proposed new models for dynamic structures of proteins and lipids which regulated the bio-communication on the membranes. From these results we demonstrated a new picture for dynamics of bio-communications on the membranes.