Neuro-immune cross talk with molecular imaging and medicine

我们开发了一种独特的技术，用于使用共聚焦激光扫描荧光显微镜研究神经免疫相互作用。我们发现，神经肥大细胞通信可以发生在没有中间转导细胞和神经肽P物质，通过NK-1受体的操作，是这种通信的可溶性因子。此外，我们发现，从活化的肥大细胞释放的ATP介导神经细胞的活化。此外，我们发现CADM 1（细胞粘附分子1）在肥大细胞和神经细胞之间的通讯中起重要作用。

We developed a unique technique for studying neuro-immune interaction with confocal laser scanning fluorescence microscopy. We found that nerve-mast cell communication can occur in the absence of an intermediary transducing cell and that the neuropeptide substance P, operating via NK-1 receptors, is a soluble factor of this communication. In addition, we showed that ATP which is released from activated mast cells mediates the activation of nerve cells. Further, we found CADM1(cell adhesion molecule 1) play an important role of the communication between mast cells and nerve cells.