Control of Internal Radiation Exgooure Based on the Analysis of Relationships between the Chemical Form and the Fugacity of Radio-nuclides

基于放射性核素化学形态与逸度关系分析的内辐射外源控制

• 批准号: 02304065
• 负责人: KURIHARA Norio
• 金额: $ 2.56万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02304065/
• 关键词: Self-decomposition of tritium-labeled compounds; Contamination by intaken tritium; Self-decomposition products from [ ^<35>S]methionine; Out-of-body measurement of positron emitters; Effective collection of tritium expiration; Simultaneous determinat

1. Tritium-labeled compounds especially[ ^3H]thymidine stored in powdered form decomposed by 5% in 6 days, 20-30% in 170 days, and completely after 800 days.2. [ ^<35>S]Methionine with stabilizers in aqueous solution decomposed to produce several volatile radioactive compounds including methyl mercaptane, methyl ethyl sulfide and ethyl propyl sulfide which were all characterized by means of HPLC.3. For estimation of internal radiation exposure by tritium in the body, an improved collection method for THO in expiration was devised.4. Relative values of RBE for THO and tritiated thymidine were determined by examining their effects on the intestine cells. The value for tritiated thymidine was larger than that for THO.5. A tritium-contamination case was found for a radioisotope user and monitoring of his urine revealed that the chemical form of the intaken tritium was THO. It indicated that non-volatile tritium-labeled compounds may decompose to give THO and may be inhaled to cause internal radiation exposure.6. Rapid excretion methods of the inhaled iodine were examined and the effect of perchlorate ion was confirmed.7. Internal radiation exposure caused by positron emitters was estimated by a new method of out-of-body radiation measurement.8. A simultaneous activity-determination procedure was devised for a sample containing ^3H, ^<14>C, ^<32>P, ^<35>S, ^<51>Cr and ^<125>I by means of a newly devised combustion flask.

1.氚标记化合物，特别是[ ^3H]胸苷，以粉末形式贮存，6天内分解5%，170天分解20-30%，800天后完全分解. [ ^<35>S]甲硫醇与稳定剂在水溶液中分解生成几种挥发性的放射性化合物，包括甲硫醇、甲基乙基硫醚和乙基丙基硫醚，它们都通过HPLC进行了表征.为估算氚在体内的内照射量，设计了一种改进的呼气THO采集方法.通过检查THO和氚化胸苷对肠细胞的影响来确定它们的RBE相对值。氚化胸苷的值大于TH。发现了一个放射性同位素使用者的氚污染病例，对他的尿液进行监测发现，摄入的氚的化学形式是THO。这表明，非挥发性氚标记化合物可能分解产生THO，并可能被吸入引起内辐射中毒。对吸入碘的快速排泄方法进行了研究，并证实了高氯酸根离子的作用.采用一种新的体外辐射测量方法估算了正电子发射体引起的内照射量。利用一种新设计的燃烧瓶，设计了一种同时测定含^3 H、^<14>C、^<32>P、^<35>S、^<51>Cr和^<125>I的样品活度的方法。

项目成果

Kazumi Saito, Hideo Miyatake, Hiroshige Kobori and Norio Kurihara: "Quantitative determination of ^3H, ^<14>C, ^<32>P, ^<35>S, ^<51>Cr and ^<125>I on a paper disc for the contamination monitoring" Health Physics. (1992)

Kazumi Saito、Hideo Miyatake、Hiroshige Kobori 和 Norio Kurihara：“在 a 上定量测定 ^3H、^<14>C、^<32>P、^<35>S、^<51>Cr 和 ^<125>I”

斉藤 和実 他: "A combustion method for the simultaneous determination of ^3H, ^<14>C,and ^<35>S in triply labeled organic samples by liquid scintillation counting" Analytical Biochemistry. 190. 276-280 (1990)

Kazumi Saito 等人：“通过液体闪烁计数同时测定三重标记有机样品中 ^ 3 H、^ 14 C 和^ 35 S 的燃烧方法”分析生物化学190。276-280 (1990)。 ）

山本 郁子 他: "活性炭ウレタンフォ-ムを用いる均一な^<1125>1I面線源" Radioisotopes. 41. 23-26 (1992)

Ikuko Yamamoto 等人：“使用活性炭聚氨酯泡沫的均匀 ^<1125>1I 平面源”放射性同位素。

Alvaro A. Mejia, Takashi Nakamura, Masatoshi Itoh, Jun Hatazawa, Kiichi Ishiwata, Tatsuo Ido, Masaki Matsumoto, Hiroshi Watabe, Shoichi Watanuki and Shinya Seo: "Absorbed dose estimates in positron emission tomography studies based on the administration o

Alvaro A. Mejia、Takashi Nakamura、Masatoshi Itoh、Jun Hatazawa、Kiichi Ishiwata、Tatsuo Ido、Masaki Matsumoto、Hiroshi Watabe、Shoichi Watanuki 和 Shinya Seo：“基于给药的正电子发射断层扫描研究中的吸收剂量估计

Atsushi Yoshimura et al.: "Activation of argon in the air by neutron evolving from a medical small cyclotron" The 62nd Meeting of the Medical Radiation Science Society. (1992)

Atsushi Yoshimura 等人：“通过医用小型回旋加速器中产生的中子激活空气中的氩”，医学放射学会第 62 次会议。