Control of body contamination with radioisotopes during the research in biosciences

生物科学研究过程中放射性同位素身体污染的控制

• 批准号: 63304066
• 负责人: KURIHARA Norio
• 金额: $ 2.62万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63304066/
• 关键词: Radioisotopes; Body contamination; Bioscience research; Internal radiation dose; Tritium; Fluorine-18; Sulfur-35; Iodine-125; 炭素14

1. A combustion method for the simultaneous determination of ^3H, ^<14>C and ^<35>S in triply labeled organic materials by liquid scintillation counting was established.2. Tritium concentration in the laboratory was sufficiently low, when we use the newly developed tritium-safety-clean-cabinet even with 130 MBq of tritium evaporated.3. When we use an inner box during a tritium experiment, tritium concentration in the air can be reduced much more efficiently.4. A safe sealing device for an ampoule containing tritium water was developed.5. A cold-trap method for collecting exhalated air was more sensitive than a commercial exhalation-collecting apparatus.6. An automatic air sampler for tritium monitoring was developed.7. Several ^<14>C-labeled compounds and [^<35>S]methionine were examined for their metabolism and disposition in,rats, and their excretion function was proposed to be reexamined before evaluating radiation doses.8. ^<125>I monitoring system using a NaI(Tl) survey meter was established.9. A flow monitoring method for ^<125>I was established.10. It was found that the body contamination with ^<125>I can be avoided with a proper procedure conducted in a well-ventilated hood.11. Absorbed doses due to i.v. administration of ^<18>F-fluorodeoxy- glucose in PET studies were estimated.

1.建立了燃烧<14><35>法液体闪烁计数法同时测定三重标记有机物中^3H、^ C和^ S的方法.使用新研制的氚安全洁净柜，即使蒸发130 MBq的氚，实验室中的氚浓度也足够低.在氚实验中使用内盒可以更有效地降低空气中的氚浓度.研制了含氚水储罐的安全密封装置.收集呼出气体的冷阱方法比商业呼气收集装置更敏感。研制了用于氚监测的自动空气采样器.研究了几种~ 1C<14>标记化合物和[~ 1 <35>S]蛋氨酸在大鼠体内的代谢和处置，并建议在评估辐射剂量前重新研究其排泄功能。建立<125>了NaI（Tl）测量仪监测系统.建立了一种碘的流量监测方法<125>。结果发现，<125>在通风良好的通风橱中进行适当的程序，可以避免^ I对人体的污染。估计了PET研究中由于i. v.施用13 <18>F-氟脱氧葡萄糖而引起的吸收剂量。

项目成果

Kazumi Saito et al.: "A combustion method for the simultaneous determination of ^3H, ^<14>C and ^<35>S in triply labeled organic materials by liquid scintillation counting" Anal. Biochem.(1990)

Kazumi Saito 等人：“通过液体闪烁计数同时测定三重标记有机材料中 ^ 3 H、^ 14 C 和 ^ 35 S 的燃烧方法” Anal。

Kunihide Nishizawa et al.: "Monitroing of ^<131>I in milk and rain water in Japan following the reactor accident at Chrnobyl and estimates of human thyroidal dose equivalents" Health Physics, 55, 773-777, 1988.

Kunihide Nishizawa 等人：“切尔诺贝利反应堆事故后日本牛奶和雨水中 ^<131>I 的监测以及人体甲状腺剂量当量的估计”健康物理学，55, 773-777, 1988。

Kazumi Saito et al.: "A combustion method for the simultaneous determination of ^3H,^<14>C and ^<35>S in triply labeled organic materials by liquid scintillation counting" Aanl.Biochem.(投稿中). (1990)

Kazumi Saito等人：“通过液体闪烁计数同时测定三重标记有机材料中的 3 H、 14 C和 35 S的燃烧方法”Aanl.Biochem.(进行中)。 ）

A.A.Mejia et al.: "Estimation of absorbed doses in Japanese due to intravenous administration of ^<18>F-fluorodeoxyglucose in PET studies" (1990)

A.A.Mejia等人：“日本人在PET研究中由于静脉注射18F-氟脱氧葡萄糖而吸收剂量的估计”(1990)

Kunihide Nishizawa et al.: "Monitoring of ^<131>I in milk and rain water in Japan following the reactor accident at Chernobyl and estimates of human thyoidal dose equivalents" Health Physics. 55. 773-777 (1988)

Kunihide Nishizawa 等人：“切尔诺贝利反应堆事故后日本牛奶和雨水中 ^<131>I 的监测以及人体甲状腺剂量当量的估计”健康物理学。