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Red blood cell carbonic anhydrase I and zinc concentrations reflect a patient's integrate thyroid hormone level over the previous few months

红细胞碳酸酐酶 I 和锌浓度反映了患者前几个月的综合甲状腺激素水平

基本信息

批准号：
02807222
负责人：
YOSHIDA Katsumi
金额：
$ 0.9万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02807222/
关键词：
Thyroid hormone Red blood cell Carbonic anhydrase Zinc 炭酸脱水酵素

项目摘要

The red blood cell(RBC)carbonic anhydrase I(CAI)and zinc(Zn)concentrations were measured in 28 healthy volunteers, 46'patients with hyperthyroid Graves' disease, 10 patients with subacute thyroiditis, 6 patients with silent thyroiditis and 4 patients with syndrome of inappropriate thyrotropin secretion(SITSH). The concentration of RBC CAI was correlated to a significant extent(r=0.95)with the RBC Zn concentration. Both the RBC CAI and Zn concentrations were decreased in approximately 90% of the hypertyroid patients with Graves' disease. Following antithyroid therapy the normalization of these substances lagged behind that of plasma thyroid hormone levels by about 2 months. Furthermore. the highest correlation was observed between the RBC CAI and Zn and the plasma T4 and T3 levels measured 8 weeks earlier. Both the RBC CAI and Zn concentrations were normal in patients with subacute thyroiditis and silent thyroiditis in whom the plasma levels of T4 and T3 were elevated. The patients with SITSH who were clinically hyperthyroid had subnormal values, but clinically euthyroid patients had normal values. These results suggest that 1)both the RBC CAI and Zn concentrations in patients with hyperthyroidism reflect the patient's mean thyroid hormone level over the preceding several months. 2)in patients with subacute thyroiditis and silent thyroiditis, elevation of plasma thyroid hormone concentrations is transient and causes little change in these substances. And the measurement of RBC CAI and Zn concentrations may be useful clinically as follows : 1)in differentiating hyperthyroid Graves'disease from transient hyperthyroidism due to destructive thyroiditis ; 2)as a marker of the peripheral tissue response to thyroid hormone : and 3)in obtaining an accurate estimate of the extent of elevated thyroid hormone levels in hyperthyroid patients over time.

测定了28例健康志愿者、46例甲亢性Graves病、10例亚急性甲状腺炎、6例无症状甲状腺炎和4例促甲状腺激素分泌异常综合征(SITSH)患者的红细胞(RBC)、碳酸氢酶I(CaI)和锌(Zn)含量。红细胞CA1浓度与红细胞锌浓度呈显著正相关(r=0.95)。约90%的甲亢性Graves病患者的红细胞免疫抑制指数和锌浓度均降低。在抗甲状腺治疗后，这些物质的正常化滞后于血浆甲状腺激素水平约2个月。更重要的是。8周前测定的血浆T_4、T_3水平与红细胞形态指数、锌的相关性最高。亚急性甲状腺炎和无症状性甲状腺炎患者血浆T4、T3水平均升高，RBC-CA1和锌浓度均正常。临床甲亢的SITSH患者的甲亢值低于正常值，而临床正常的甲亢患者的甲亢值则低于正常值。这些结果提示：1)甲亢患者的红细胞指数和锌浓度均能反映患者前几个月的平均甲状腺激素水平。2)在亚急性甲状腺炎和无症状甲状腺炎患者中，血浆甲状腺激素浓度升高是一过性的，对这些物质的影响不大。RBC、CAI和锌浓度的测定可用于临床：1)鉴别甲亢性Graves病和破坏性甲状腺炎所致的一过性甲亢；2)作为外周组织对甲状腺激素反应的标志物；3)准确估计甲亢患者随时间推移甲状腺激素水平升高的程度。