Is inhibition of thyroid hormone activation involved in methylmercury toxicity in the developing brain?
Is inhibition of thyroid hormone activation involved in methylmercury toxicity in the developing brain?
批准号:
19510065
负责人:
YOSHIDA Katsumi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
We examined the association of MeHg toxicity with deiodinases which regulate activation (D2) and inactivation (D3) of thyroid hormone by using cultured rat astrocytes or a human breasy cancer cell line MCF-7. MeHg significantly inhibited D2 and D3 activity. However, it did not affect the expression of D2 and D3 mRNA and protein. These results indicate that MeHg may disturb normal brain development through D2 and D3 inhibition.
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会议论文
Methylmercury inhibition of type II5'一deiodinase activity resulting in a decrease in growth hormone production in GH3 cells.
甲基汞抑制 II5-脱碘酶活性,导致 GH3 细胞中生长激素产生减少。
DOI:
--
发表时间:
2007
期刊:
Toxicology 237
影响因子:
--
作者:
[Abrosimov A, et. al., Mori K]
通讯作者:
Mori K
重金属の2型脱ヨード酵素遺伝子発現に及ぼす影響
重金属对2型脱碘酶基因表达的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[竹田真由, 岩瀬裕章, 森弘毅, 尾崎泰, 中川吉則, 平林佐依子, 伊藤貞嘉, 吉田克己]
通讯作者:
吉田克己
Development of novel environment-resistant interphase for ceramic-based composites using nanolayered-ternary carbides
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批准号:18K18938
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$4.08万
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财政年份:2018
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负责人:YOSHIDA Katsumi
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依托单位:
Thing, property, the right and the relation of attribution with the object-A perspective for new law of property beyond the 'Pandektenwissenschaft'
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批准号:22653009
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资助金额:$2.16万
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财政年份:2010
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依托单位:
Development of porous ceramics for exhaust gas purification based on in-situ crystal growth and grain orientation
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批准号:21750204
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资助金额:$3.0万
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财政年份:2009
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负责人:YOSHIDA Katsumi
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依托单位:
Collaboration of the Public and Private in forming Order to the 20013021Market/Living Environment: The Legal Structure of <<Public Sphere>>.
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批准号:17203007
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$23.88万
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财政年份:2005
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负责人:YOSHIDA Katsumi
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依托单位:
A Strategic Study to Replace the Current Fluid Legal System by a Better Integrated One for the 21st Century-A Comparative Study of Administration, Market, and Consumption Aspects of Modern Society.
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批准号:14202006
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依托单位:
Development of risk reduction for health promotion strategy based on data-mining
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批准号:13470099
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资助金额:$5.12万
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财政年份:2001
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负责人:YOSHIDA Katsumi
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依托单位:
The Construction of the Legal System for Supporting Autonomy
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批准号:12620001
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2000
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负责人:YOSHIDA Katsumi
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依托单位:
Red blood cell carbonic anhydrase and zinc concentrations reflect a patient's mean thyroid hormone level over the previous two months.
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批准号:09671017
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:1997
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负责人:YOSHIDA Katsumi
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依托单位:
Epidemiological isk assessment based on structural equations with latent variables
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批准号:09470119
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$2.24万
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财政年份:1997
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负责人:YOSHIDA Katsumi
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依托单位:
Development of health education system based on individual health risk
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批准号:05670365
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1993
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负责人:YOSHIDA Katsumi
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依托单位:
Red blood cell carbonic anhydrase I and zinc concentrations reflect a patient's integrate thyroid hormone level over the previous few months
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批准号:02807222
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.9万
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财政年份:1990
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负责人:YOSHIDA Katsumi
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依托单位:
Evaluation of Methods Concerning Health Risk Based on Artificial Intelligence
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批准号:01570323
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1989
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负责人:YOSHIDA Katsumi
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依托单位:
Effects of exposures to various air pollutants on experimental asthma induction, in particular on its late asthmatic response.
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批准号:60570253
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.02万
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财政年份:1985
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负责人:YOSHIDA Katsumi
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依托单位:
海外基金