Integration of the various receptor transmitter systems in the central nervous system -with special reference to the receptor autoradiography

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We established the procedures of receptor in vitro macro autoradiographical methods for neurotransmitter system in the central nervous system. By using these methods, we investigated the hemi-parkinsonian rats which were induced by the administration of 6-OHDA in the left substantia nigra. In the stratum of the hemi-parkisonian rats, dopaminergic receptors showed the up-regulation and dopamine uptake sites were completely disappeared. On the other hand, we could not find out the alteration of the cholinergic receptors concentration.Administration of ibotenic acid to the Meynert nucleus, we induced expeimental dementia rats. In these rats, the cholinergic receptors in the cerebral cotex were disapperared.The experimental ischemic rats were made by occulusion of the mid cerebral artery for 1 hour. We investigated the GABAnergic receptors in the ischemic rats brain using as ligands, 3H-labeled muscimol and SR 95531, which are considered much more specific binding ligand for GABA A receptor. As a results, GABAnergic receptors in the ischemic regions were significantly and simutanenously decreased.