Real-Time Digital Autoradiography System

实时数字放射自显影系统

• 批准号: 7794778
• 负责人: Todd E Peterson
• 金额: $ 15.99万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-29 至 2011-07-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794778
• 关键词: Animals; Applications Grants; Autoradiography; Biological Process; Bioluminescence; Core Facility; Data; Fluorescence; Funding; Image; Institutes; Investigation; Magnetic Resonance Imaging; Metric; Microtome - medical device; Positron-Emission Tomography; Process Assessment; Qualifying; Radiolabeled; Research Project Grants; Resolution; Resources; Science; Scientist; System; Therapeutic Intervention; Time; Training Programs; Ultrasonography; Universities; Validation; X-Ray Computed Tomography; cancer imaging; digital; experience; imaging modality; in vivo; instrumentation; molecular imaging; radiotracer; single photon emission computed tomography; tissue slice preparation

DESCRIPTION (provided by applicant): This shared instrumentation grant proposal is for the purchase of a digital, real-time autoradiography system with multiple radiolabel capability. The NIH-funded research projects that require this system are aimed primarily at developing new molecular imaging agents and validating existing radiotracers for the investigation of fundamental biological processes and the assessment of the impact of therapeutic interventions. The system will be located in the Center for Small Animal Imaging (CSAI) alongside systems representing the major in vivo imaging modalities (ultrasound, bioluminescence/fluorescence, X-ray CT, PET, SPECT, MRI and MRS). The CSAI also has a cryo-microtome that will facilitate the preparation of tissue slices for autoradiography. A key benefit of the autoradiography capability to many of the studies will be the opportunity to obtain high-resolution, quantitative data to assist in the interpretation and validation of in vivo imaging metrics. The CSAI functions as a Core Facility for the university and operates as part of the Vanderbilt University Institute of Imaging Science. The autoradiography system will be supported by an experienced group of imaging scientists and a highly qualified support staff. It also will be a key resource for postdoctoral trainees supported by our institutional training program in cancer imaging as well as our other trainees in imaging science.

描述（由申请人提供）：此共享仪器赠款提案用于购买具有多个放射线标记功能的数字实时自显影系统。需要该系统的NIH资助的研究项目主要旨在开发新的分子成像剂，并验证现有的放射性示例，以研究基本生物学过程和评估治疗干预措施的影响。该系统将位于小动物成像中心（CSAI），以及代表主要体内成像方式的系统（超声，生物发光/荧光，X射线CT，PET，PET，SPECT，MRI和MRS）。 CSAI还具有一个冷冻微观体，可促进组织切片以进行放射自显影。放射自显影能力对许多研究的关键优势将是获得高分辨率，定量数据的机会，以帮助对体内成像指标的解释和验证。 CSAI是该大学的核心设施，并作为范德比尔特大学成像科学研究所的一部分。自显影系统将得到一群经验丰富的成像科学家和高素质的支持人员的支持。这也将是通过我们的癌症成像机构培训计划以及我们成像科学学士学位的机构培训计划支持的博士后学员的关键资源。