Studies on the relationship between demyelination and non-immnologically induced Ia antigen.

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To clarify the Implication of the major histocompatibility complex class II(Ia)antigen Induction In microglia following the Wallerian degeneration in the central nervous system(CNS), experimental allergic encephalitis(EAE)was adoptively transferred to Lewis rats In which Ia antigens had been Induced in microglia at the sites of Wallerian degeneration. In addition, to randomly distributed typical EAE lesions, the recipient rats developed distinct inflammatory lesions In accord with the distribution of Ia-positive microglia ; l. e., In the ipsilateral thalamus after cortical injury, and In the Ipsilateral optic nerve, the contralateral optic tract and superlor colliculus after unilateral eye ball enucleation. Thus, the EAE locus may be targeted by this approach. When examined using monoclonal antibody surface markers of lymphocytes, the types of lymphocytes did not differ from those In ordinary EAE lesions In the spinal cord. The potential role of nonlmmunologically induced Ia-positive cell clusters that serve as a target for autoimmune CNS diseases was discussed.