Superoxide dismutase 1 in patients with dementia of the Alzheimer type.

阿尔茨海默型痴呆患者的超氧化物歧化酶 1。

• 批准号: 02670358
• 负责人: URAKAMI Katsuya
• 金额: $ 1.41万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670358/
• 关键词: Dementia of the Alzheimer type; Superoxide dismutase; Skin fibroblast; アルツハイマ-型痴呆; Superoxide dismutase1; Superoxide dismutase 1; 赤血球

We examined superoxide dismutase (SOD) in patients with dementia of the Alzheimer type (DAT). The DAT patients were divided into two subgroups as follows : Alzheimer's disease (AD) that develops before 65 years of age and senile dementia of the Alzheimer type (SDAT) that develops after 65 years of age. We examined SOD levels in erythrocyte, serum, cerebrospinal fluid (CSF) and fibroblast. SOD levels in skin fibroblast of DAT showed abnormality. The change of SOD mRNA was closely correlate with that of protein levels of SOD. SOD in erythrocyte, serum and CSF in Parkinson's disease were significantly lower than those in controls.

我们检测了阿尔茨海默型痴呆(DAT)患者的超氧化物歧化酶(SOD)。DAT患者被分为两个亚组：65岁之前发展的阿尔茨海默病(AD)和65岁后发展的阿尔茨海默型老年痴呆(SDAT)。检测红细胞、血清、脑脊液和成纤维细胞中超氧化物歧化酶的含量。DAT患者皮肤成纤维细胞中超氧化物歧化酶水平异常。超氧化物歧化酶基因表达的变化与超氧化物歧化酶的蛋白水平密切相关。帕金森病患者红细胞、血清和脑脊液中超氧化物歧化酶含量均显著低于正常对照组。

项目成果

Urakami K et al: "Decreased superoxide dismutase activity in erythrocyte in Parkinson's disease." Jpn J Psychiatr Neurol. 46. 933-936 (1992)

Urakami K 等人：“帕金森病患者红细胞中的超氧化物歧化酶活性降低。”

浦上 克哉: "アルツハイマー型痴呆患者皮膚線維芽細胞におけるCu,Zn superoxide dismutase(SOD)異常" 神経内科. 37. 419-420 (1992)

Katsuya Urakami：“阿尔茨海默病患者皮肤成纤维细胞中的铜、锌超氧化物歧化酶 (SOD) 异常”《神经病学》37. 419-420 (1992)。

Urakami K: "Decreased superoxide dimutase activity in erythrocyte in Parkinson's disease." Jpn J Psychiatr Neuvol. 46. 933-936 (1992)

Urakami K：“帕金森病患者红细胞中超氧化物歧化酶活性降低。”