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Superoxide dismutase 1 in patients with dementia of the Alzheimer type.

Superoxide dismutase 1 in patients with dementia of the Alzheimer type.
阿尔茨海默型痴呆患者的超氧化物歧化酶 1。
批准号:
02670358
负责人:
URAKAMI Katsuya
金额:
$1.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1990
资助国家:
日本
项目状态:
已结题
起止时间:
1990 至 1992

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中文摘要
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英文摘要
We examined superoxide dismutase (SOD) in patients with dementia of the Alzheimer type (DAT). The DAT patients were divided into two subgroups as follows : Alzheimer's disease (AD) that develops before 65 years of age and senile dementia of the Alzheimer type (SDAT) that develops after 65 years of age. We examined SOD levels in erythrocyte, serum, cerebrospinal fluid (CSF) and fibroblast. SOD levels in skin fibroblast of DAT showed abnormality. The change of SOD mRNA was closely correlate with that of protein levels of SOD. SOD in erythrocyte, serum and CSF in Parkinson's disease were significantly lower than those in controls.
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Urakami K et al: "Decreased superoxide dismutase activity in erythrocyte in Parkinson's disease." Jpn J Psychiatr Neurol. 46. 933-936 (1992)
Urakami K 等人:“帕金森病患者红细胞中的超氧化物歧化酶活性降低。”
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浦上 克哉: "アルツハイマー型痴呆患者皮膚線維芽細胞におけるCu,Zn superoxide dismutase(SOD)異常" 神経内科. 37. 419-420 (1992)
Katsuya Urakami:“阿尔茨海默病患者皮肤成纤维细胞中的铜、锌超氧化物歧化酶 (SOD) 异常”《神经病学》37. 419-420 (1992)。
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Dementia Prevention - Early Detection by Olfactory Function Test and Prevention by Aromatherapy
  • 批准号:
    20K07886
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.75万
  • 财政年份:
    2020
  • 负责人:
    URAKAMI Katsuya
  • 依托单位:
The analysis of altered glycosylation in Alzheimer's disease
  • 批准号:
    22590933
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.66万
  • 财政年份:
    2010
  • 负责人:
    URAKAMI Katsuya
  • 依托单位:
Clinical utilization of β-Acl, newly identified Aβ associated protein, as a novel diagnostic marker of Alzheimer's disease.
  • 批准号:
    18590940
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.5万
  • 财政年份:
    2006
  • 负责人:
    URAKAMI Katsuya
  • 依托单位:
Analysis of the relationship between Amyloid β protein and cholesterol in Alzheimer's disease.
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