The analysis of altered glycosylation in Alzheimer's disease

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We measured the contents of the sugar chain in two glycoproteins which has altered glycosylation in Alzheimer’s disease (AD), one is transferrin and another is the protein associated with immune system, temporally named protein X. We indicated both of them had decreased glycosylation in very early stage of AD. The decreased levels of glucosylation of protein X was correlated with the altered levels of cerebrospinal fluid (CSF) amyloid β protein. The altered sugar chain of protein X in Alzheimer’s serum must be a 優秀な biological marker for diagnosis of AD, that monitors the change in the brain or CSF derived from the brain. On the other way, we also found the decreased levels of a-2, 6-sialyltransferase (STase) in Alzheimer’s serum. STase is the enzyme which adds the sialic acid to the transferrin. This indicates the decreased sialylation of Alzheimer’s serum transferrin is 原因であるby the altered STase. These two changes in glycoproteins suggest the 異常なglycosylation 密接にassociates the pathophysiology of AD