The analysis of altered glycosylation in Alzheimer's disease

阿尔茨海默氏病糖基化改变的分析

• 批准号: 22590933
• 负责人: URAKAMI Katsuya
• 金额: $ 2.66万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590933/
• 关键词: アルツハイマー病; 脳神経疾患; 糖鎖; 診断マーカー; アルツハイマー型認知症

We measured the contents of the sugar chain in two glycoproteins which has altered glycosylation in Alzheimer’s disease (AD), one is transferrin and another is the protein associated with immune system, temporally named protein X. We indicated both of them had decreased glycosylation in very early stage of AD. The decreased levels of glucosylation of protein X was correlated with the altered levels of cerebrospinal fluid (CSF) amyloid β protein. The altered sugar chain of protein X in Alzheimer’s serum must be a 優秀な biological marker for diagnosis of AD, that monitors the change in the brain or CSF derived from the brain. On the other way, we also found the decreased levels of a-2, 6-sialyltransferase (STase) in Alzheimer’s serum. STase is the enzyme which adds the sialic acid to the transferrin. This indicates the decreased sialylation of Alzheimer’s serum transferrin is 原因であるby the altered STase. These two changes in glycoproteins suggest the 異常なglycosylation 密接にassociates the pathophysiology of AD

We measured the contents of the sugar chain in two glycoproteins which has altered glycosylation in Alzheimer’s disease (AD), one is transferrin and another is the protein associated with immune system, temporally named protein X. We indicated both of them had decreased glycosylation in very early stage of AD. The decreased levels of glucosylation of protein X was correlated with the altered levels of cerebrospinal fluid (CSF) amyloid β protein. The altered sugar chain of protein X in Alzheimer's serum must be a excellent biological marker for diagnosis of AD, that monitors the change in the brain or CSF derived from the brain. On the other way, we also found the decreased levels of a-2, 6-sialyltransferase (STase) in Alzheimer’s serum. STase is the enzyme which adds the sialic acid to the transferrin. This indicates the decreased sialylation of Alzheimer's serum transferin is caused by the altered STase. These two changes in glycoproteins suggest the abnormal <$glycosylation associates the pathology of AD

项目成果

Taniguchi Msylation of serum protein as a new diagnostic marker for Alzheimer's disease.

Taniguchi 将血清蛋白甲基化作为阿尔茨海默病的新诊断标记物。

• 发表时间: 2013
• 作者: 海野敏紀;渡瀬啓;水澤英洋;Taniguchi M
• 通讯作者: Taniguchi M

認知症は怖くない 18のワケ

痴呆症并不可怕的 18 个理由

• 发表时间: 2011
• 作者: Kamihira S.;Yamano Y.;Iwanaga M.;et al.;三宅彩香，他;朝倉邦彦;浦上克哉;三木康生,冨山誠彦,新井陽ほか8名;村上真樹，他;浦上克哉
• 通讯作者: 浦上克哉

要支援高齢者の認知機能とADL,介護負担感の関連における在宅支援の検討

检查与需要支持的老年人的认知功能、ADL 和护理负担感相关的家庭支持

• 发表时间: 2010
• 作者: 崎山佑介;大窪隆一;西郷隆二;徳永章子;平野隆城;山下秀一;塩見一剛;高嶋 博;宮崎育子,他;古川芳明;福田敏秀
• 通讯作者: 福田敏秀

アルツハイマー型認知症早期発見のための嗅覚検査(続報)

早期发现阿尔茨海默氏痴呆症的嗅觉测试（后续）

• 发表时间: 2010
• 作者: Kamouchi M;et al;阿部陽一郎;神保太樹
• 通讯作者: 神保太樹

認知症診療に必要な基礎知識

痴呆症治疗所需的基础知识

• 发表时间: 2010
• 作者: Ago T;et al;Chikako Nito;浦上克哉
• 通讯作者: 浦上克哉