Biochemical Markers of Melanoma Utilizing Melanin Formation

利用黑色素形成的黑色素瘤的生化标志物

基本信息

  • 批准号:
    02670487
  • 负责人:
  • 金额:
    $ 1.15万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 财政年份:
    1990
  • 资助国家:
    日本
  • 起止时间:
    1990 至 1992
  • 项目状态:
    已结题

项目摘要

1. Significance of melanin-related metabolites as biochemical markers of melanoma(1) Normal values of 5-S-cysteinyldopa(5-S-CD) and 6-hydroxy-5-methoxyindole-2-carboxylic acid(6H5MI2C) in serum and urine were obtained from 33 healthy Japanese. The urinary excretion of both markers showed significant decrease in elderly subjects as compared with middle-aged subjects, while the serum concentration showed no age-dependent differences.(2) Values of those 4 markers in melanoma patients have regularly been followed. Among the 4 markers serum 5-S-CD appears to reflect most sensitively the progression of melanoma.Some patients showed pathological values of serum 5-S-CD(above 10 nmol/L) prior to the detection by image diagnosis. On the other hand, 6H5MI2C in serum and urine was found to be of little clinical significance.(3) Serum 5-S-CD values have been analyzed every month in 2 years' period in 10 healthy subjects. No values exceeded 10 nmol/L, the upper limit of normal value, in the 240 samples.2. Improvement of HPLC determination of serum 5-S-CD The previous method for the HPLC determination of serum 5-S-CD required 80 min for each chromatographic run. Pre-treatment of serum samples has been improved to reduce the time for each analysis to 40 min, which enabled to double the analytical capacity.
1.黑色素相关代谢物作为黑色素瘤生化标志物的意义(1)测定了33名健康日本人血清和尿液中5-S-半胱氨酰多巴(5-S-CD)和6-羟基-5-甲氧基吲哚-2-羧酸(6 H_5 MI_2C)的正常值。与中年受试者相比,老年受试者的这两种标志物的尿液排泄量显着减少,而血清浓度没有显示出年龄依赖性差异。(2)这4种标记物在黑色素瘤患者中的值已定期随访。其中血清5-S-CD对黑色素瘤的进展最为敏感,部分患者在影像学诊断前血清5-S-CD已超过10 nmol/L。而血清和尿液中的6 H5 MI 2C则无临床意义。(3)本文对10名健康人的血清5-S-CD值进行了2年每月测定。240份样本中,没有一份超过正常值上限10 nmol/L.血清5-S-CD高效液相色谱测定方法的改进以前的血清5-S-CD高效液相色谱测定方法每次色谱运行需要80 min。改进了血清样品的预处理,将每次分析的时间减少到40分钟,从而使分析能力增加一倍。

项目成果

期刊论文数量(21)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Takashi HORILOSHI: "Serum 5-S-cysteinyldopa(5-S-CD)as a marker of melanoma progression" Journal of Dermatology. 19. 809-813 (1992)
Takashi HORILOSHI:“血清 5-S-半胱氨酰多巴 (5-S-CD) 作为黑色素瘤进展的标志物”皮肤病学杂志。
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  • 影响因子:
    0
  • 作者:
  • 通讯作者:
堀越 貴志,伊藤 祥輔,若松 一雄,小野寺 英夫,江口 弘晃,川村 邦子,高橋 誠: "血清5ーSーCD(5ーSーcysteinyldopa)の変動と悪性黒色腫の予後" 皮膚悪性腫瘍.
Takashi Horikoshi、Shosuke Ito、Kazuo Wakamatsu、Hideo Onodera、Hiroaki Eguchi、Kuniko Kawamura、Makoto Takahashi:“血清 5-SCD(5-S-半胱氨酰多巴)的变化和恶性黑色素瘤的预后”皮肤恶性肿瘤。
  • DOI:
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  • 影响因子:
    0
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Kazumasa WAKAMATSU: "Comparison of melanin-related metabolites as markers of melanoma. Stability and correlation" Advances in Tryptophan Research 1992(Eds.I.Ishiguro,et al.),Fujita Health Univ.Press. 231-234 (1992)
Kazumasa WAKAMATSU:“黑色素相关代谢物作为黑色素瘤标志物的比较。稳定性和相关性”色氨酸研究进展 1992(Eds.I.Ishiguro 等人),Fujita Health Univ.Press。
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  • 影响因子:
    0
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  • 通讯作者:
Shosukee ITO: "Melanin-related metabolites as markers of melanoma:A review" Journal of Dermatology. 19. 802-805 (1992)
Shosukee ITO:“黑色素相关代谢物作为黑色素瘤的标志物:综述”皮肤病学杂志。
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  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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  • 通讯作者:
Kazumasa Wakamatsu;Shosuke Ito: "Urinary Excretion and Serum Concecentation of 5-S-Cysteinyldopa and 6-Hydroxy-5-methoxyindole-2-carboxylic Acid in Normal Subjects" Malanoma Research. 1. 141-147 (1991)
Kazumasa Wakamatsu;Shosuke Ito:“正常受试者中 5-S-半胱氨酰多巴和 6-羟基-5-甲氧基吲哚-2-羧酸的尿排泄和血清浓度”疟疾研究。
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  • 影响因子:
    0
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ITO Shosuke其他文献

ITO Shosuke的其他文献

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{{ truncateString('ITO Shosuke', 18)}}的其他基金

Elucidation of ultraviolet radiation-induced physiological degradation pathway of eumelanin and pheomelanin and its physiological significance
紫外辐射诱导的真黑素和褐黑素生理降解途径及其生理意义的阐明
  • 批准号:
    26461705
  • 财政年份:
    2014
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Elucidation of ultraviolet radiation-induced physiological degradation pathway of eumelanin and pheomelanin
阐明紫外线辐射诱导的真黑素和褐黑素的生理降解途径
  • 批准号:
    23591659
  • 财政年份:
    2011
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Control mechanism of melanogenesis by pigmentation-related genes and ultraviolet radiation
色素沉着相关基因和紫外线对黑色素生成的控制机制
  • 批准号:
    20591357
  • 财政年份:
    2008
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Mechanism of regulation of melanin synthesis by coat color genes and ultraviolet radiation in mice and human
毛色基因和紫外线调节小鼠和人类黑色素合成的机制
  • 批准号:
    18591262
  • 财政年份:
    2006
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Regulation mechanism of melanin production by related-genes and UV.
相关基因和紫外线对黑色素生成的调控机制。
  • 批准号:
    14570829
  • 财政年份:
    2002
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Genetic and non-genetic regulation mechanism of melanin production in the mammal
哺乳动物黑色素产生的遗传和非遗传调控机制
  • 批准号:
    12670844
  • 财政年份:
    2000
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
ANALYSIS OF REGULATIVE FUNCTION OF MELANIN-RELATED GENE EXPRESSION BY BIOCHEMICALAND CELLULAR BIOLOGICAL METHODS
生物化学和细胞生物学方法分析黑色素相关基因表达的调控功能
  • 批准号:
    10670812
  • 财政年份:
    1998
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Functions of Melanogenesis-Related Genes by Chemical and Biochemical Methods
通过化学和生化方法研究黑素生成相关基因的功能
  • 批准号:
    07670971
  • 财政年份:
    1995
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Biosynthesis of Eumelanin in Melanoma and Biochemical Markers of Melanoma
黑色素瘤中真黑素的生物合成及黑色素瘤的生化标志物
  • 批准号:
    63570484
  • 财政年份:
    1988
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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开发针对葡萄膜恶性黑色素瘤关键点 MDM4 和 PKC 的新型治疗药物
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