Study of Pathogenesis in Dysphagia

吞咽困难发病机制的研究

• 批准号: 02670767
• 负责人: OKAMURA Hiroshi
• 金额: $ 1.34万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670767/
• 关键词: deglutition; dysphagia; fluorography; swallowing pressure; esophageal orifice; cricopharyngeal muscle; geriatrics; swallowing reflex; 嚥下プログラム; 嚥下圧曲線; 咽頭・食道透視; 固型造影剤; 筋電図

In this research project, normal and pathological swallowing function was evaluated through multidimensional analyses of deglutition.Investigation of Swallowing Mechanisms by Pharyngo-esophageal FluorographyThe following findings were often observed in geriatric group ; laryngeal penetration and disorder of movement of epiglottis in using liquid contrast medium and retention of bolus in the valleculla and pharyngeal splitting deglutition in using solid contrast medium. The same findings were also observed in the group with a sensation of difficulty in swallowing. These results suggest that propelling power of bolus and swallowing reflectory mechanism may be distorted in geriatric group and at the initial stage of dysphagia.Investigation of Swallowing Mechanisms by Measurements of Swallowing Pressure and Electromyographic RecordingsThe cricopharyngeal muscle mainly regulated the resting tone of the esophageal orifice and was innervated by the pharyngo-esophageal nerve unilaterally. The … More normal critical ranges of the swallowing pressure at the velopharyngeal, hypopharyngeal and cervico-esophageal regions were determined through observation of 30 normal adults. From these ranges, the classification of swallowing pressure curve which consists of 5 types was defined. The normal conduction curve of swallowing pressure was an S-like figure and this curve could visualize normal or abnormal pattern of conduction of swallowing pressure. The relaxation of the esophageal orifice started at the pharyngeal end. Therefore, to investigate the relaxation of the esophageal orifice in swallowing, it was recommended that the intraluminal pressure should be measured at the pharyngeal end. The critical ranges of the time and duration of the relaxation was also determined.Multi-dimensional Analyses of Pathogenesis of DysphogiaMulti-dimensional analyses of pathogenesis of dysphagia was investigated in 130 patients with dysphagia. The application of solid bolus for fluorography is a useful method for detecting the loss of swallowing reflex and the decrease of propelling power of bolus. The program of swallowing in the central nervous system can be clarified by the conduction curve of swallowing pressure, and the propelling power of bolus by the classification of swallowing pressure curve. Moreover, the relaxing mechanisms of the esophageal orifice are diagnosed by the measurement of the intraluminal pressure at the pharyngeal end. Less

在本研究项目中，正常和病理吞咽功能进行了评估，通过多方面的分析deglation.Investigation吞咽机制咽食管荧光造影以下结果往往观察到在老年组：喉穿透和会厌运动障碍，在使用液体造影剂和保留团在谷和咽分裂吞咽固体造影剂。在吞咽困难感组中也观察到相同的发现。结果提示，老年组和吞咽困难初期，食团推进力和吞咽反射机制可能发生畸变。吞咽压力和肌电记录对吞咽机制的研究颈咽肌主要调节食管口的静息张力，受单侧咽食管神经支配。的 ...更多信息 通过对30例正常成人的观察，确定了咽、下咽、颈食管区吞咽压力的正常临界范围。在此基础上，定义了吞咽压力曲线的5种类型。正常吞咽压力传导曲线呈S形，可显示正常或异常吞咽压力传导模式。食管口松弛始于咽端。因此，为了研究吞咽时食管口的松弛，建议在咽端测量腔内压力。对130例吞咽障碍患者进行了吞咽障碍发病机制的多维分析。应用固体团注造影是检测吞咽反射丧失和团注推进力下降的有效方法。通过吞咽压力传导曲线可以明确中枢神经系统的吞咽程序，通过吞咽压力曲线的分类可以明确弹丸的推进力。此外，通过测量咽端的管腔内压力来诊断食管口的松弛机制。少

项目成果

丘村 煕,森 敏裕,稲木 匠子: "Hypopharyngeal Stricture (in Recent Advances in BronchoーEsophagology (edーby Inoue T))" Excerpta Medica, 600(227-232) (1990)

Hiro Okamura、Toshihiro Mori、Takuko Inagi：“下咽狭窄（支气管食管学的最新进展（由 Inoue T 编辑））” Excerpta Medica，600(227-232) (1990)

稲木 匠子,丘村 煕,森 敏裕: "Radiographic Evaluation of Pharyngeal Swallowing (in Otorhinolaryngology.Head and Neck Sargery,od.by Sacritan,T.)" Kugler publication, 3206(3011-3013) (1991)

Takuko Inagi、Hiro Okamura、Toshihiro Mori：“咽部吞咽的放射学评估（在 Otorhinolaryngology.Head and Neck Sargery，od.Sacritan,T.）” Kugler 出版物，3206(3011-3013) (1991)

Hiroshi Okamura Toshihiro Mori: "Surgical treatment of Functional Dysphagia" J Clin Exper Med. 154, No. 11. 11687-690 (1990)

Hiroshi Okamura Toshihiro Mori：“功能性吞咽困难的手术治疗”J Clin Exper Med。

丘村 煕,森 敏裕,稲木 匠子: "神経筋疾患による嚥下障害" 日気食会報. 42. 400-406 (1991)

Hei Okamura、Toshihiro Mori、Takuko Inagi：“神经肌肉疾病引起的吞咽困难”Nippon Shokukai Newsletter 42. 400-406 (1991)。

Hiroshi Okamura Shoko Inaki Kouji Fukui Ryiuchi Aibara: "Pharyngeal Swallowing Function in the Elderly -Videofluoroscopic Observations-" J Jpn Bronchoesophagol Soc. 42, No. 2. 116-120 (1991)

冈村浩 翔子 稻城晃司 福井龙内 相原龙一：“老年人的咽部吞咽功能 - 电视透视观察 -” J Jpn Bronchoesophagol Soc。