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RELATIONSHIP BETWEEN GLYCOSAMINOGLYCANS IN THE TRABECULAR TISSUE AND THE INTRAOCULAR PRESSURE IN GLAUCOMAS

青光眼小梁组织中的糖胺聚糖与眼内压之间的关系

基本信息

批准号：
02670790
负责人：
TAWARA Akihiko
金额：
$ 1.47万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

项目摘要

1) The anterior chamber angle tissues obtained by trabeculectomy from the patients with goniodysgenetic glaucoma of early and late-onset were examined histologically and histochemically using Cupromeronic Blue. The results indicate that extensively accumulated basal lamina-like material in the thick juxtacanalicular connective tissue-like tissue of goniodysgenetic glaucoma contained a great deal of heparan sulfate-type proteoglycans. The results indicate that a large accumulation of basal lamina-like material with abundant proteoglycans may be responsible for the elevation of intraocular pressure in goniodysgenetic glaucoma.2) The anterior chamber angle tissues obtained by trabeculectomy from a patient with corticosteroid-induced glaucoma were examined histologically and histochemically. In the juxtacanalicular connective tissue and in the intertrabecular spaces of the outer corneoscleral trabecular meshwork, there were accumulations of fine fibrillar and basal lamina-like extracellular matrix with a great deal of heparan sulfate-type proteoglycans. The accumulations of basal lamella-like material with proteoglycans are thought to have close relationship to glaucoma manifestation in corticosteroid-induced glaucoma.3) The trabecular tissues from an ecucleated eye associated with exfoliation syndrome and from the patients with exfoliation glaucoma were examined histologically and histochemically. The exfoliative materials were observed in the trabecular meshwork, iris, ciliary body and lens, but not in the choroid or retina. Cupromeronic Blue staining revealed that the exfoliative materials contained many proteoglycans in them, which might have an association with the high intraocular pressure in this type of glaucoma.

1)应用Cupromeronic Blue对早、晚发性性腺发育性青光眼小梁切除术后获得的前房角组织进行组织学和组织化学检查。结果表明，在性腺发育性青光眼厚的关节旁结缔组织样组织中广泛积累的基底层样物质中含有大量的硫酸肝素型蛋白多糖。结果表明，含有丰富蛋白多糖的基底膜样物质的大量积累可能是造成性腺发生性青光眼眼压升高的原因。2)对1例皮质激素性青光眼小梁切除术后的前房角组织进行组织学和组织化学检查。在管旁结缔组织和外角质层小梁网的小梁间隙，可见细纤维状和基底层样细胞外基质的积聚，其中含有大量硫酸肝素型蛋白多糖。含有蛋白聚糖的基底片样物质的积累被认为与皮质类固醇诱导的青光眼的青光眼表现密切相关。3)对脱屑综合征的无核眼和脱屑性青光眼患者的小梁组织进行组织学和组织化学检查。在小梁网、虹膜、睫状体和晶状体可见脱落物质，脉络膜和视网膜未见脱落物质。铜丙二酸蓝染色显示脱落物中含有大量蛋白多糖，这可能与该型青光眼的高眼压有关。