RELATIONSHIP BETWEEN GLYCOSAMINOGLYCANS IN THE TRABECULAR TISSUE AND THE INTRAOCULAR PRESSURE IN GLAUCOMAS

1)本文对早、晚发性房角发育不良性青光眼小梁切除术后的前房角组织进行了组织学和组织化学研究。结果表明，广泛积累的基底板样物质中的厚的前房角发育不良性青光眼结缔组织样组织含有大量的硫酸乙酰肝素型蛋白多糖。结果表明，房角发育不良性青光眼患者眼内压升高的原因可能与大量的基底板层样物质和蛋白多糖有关。2）对1例皮质类固醇性青光眼患者行小梁切除术后的前房角组织进行组织学和组织化学检查。外角巩膜小梁网的小梁间隙和前小管结缔组织中有大量的硫酸乙酰肝素型蛋白多糖聚集的细纤维样和基底层样细胞外基质。皮质类固醇性青光眼患者的青光眼表现与基底板层样物质和蛋白多糖的积聚密切相关。3）对剥脱综合征患者和剥脱性青光眼患者的小梁组织进行组织学和组织化学检查。在小梁网、虹膜、睫状体和透镜中观察到脱落物质，但在脉络膜和视网膜中未观察到脱落物质。铜蛋白蓝染色显示，脱落物中含有大量的蛋白多糖，这可能与青光眼的高眼压有关。

1) The anterior chamber angle tissues obtained by trabeculectomy from the patients with goniodysgenetic glaucoma of early and late-onset were examined histologically and histochemically using Cupromeronic Blue. The results indicate that extensively accumulated basal lamina-like material in the thick juxtacanalicular connective tissue-like tissue of goniodysgenetic glaucoma contained a great deal of heparan sulfate-type proteoglycans. The results indicate that a large accumulation of basal lamina-like material with abundant proteoglycans may be responsible for the elevation of intraocular pressure in goniodysgenetic glaucoma.2) The anterior chamber angle tissues obtained by trabeculectomy from a patient with corticosteroid-induced glaucoma were examined histologically and histochemically. In the juxtacanalicular connective tissue and in the intertrabecular spaces of the outer corneoscleral trabecular meshwork, there were accumulations of fine fibrillar and basal lamina-like extracellular matrix with a great deal of heparan sulfate-type proteoglycans. The accumulations of basal lamella-like material with proteoglycans are thought to have close relationship to glaucoma manifestation in corticosteroid-induced glaucoma.3) The trabecular tissues from an ecucleated eye associated with exfoliation syndrome and from the patients with exfoliation glaucoma were examined histologically and histochemically. The exfoliative materials were observed in the trabecular meshwork, iris, ciliary body and lens, but not in the choroid or retina. Cupromeronic Blue staining revealed that the exfoliative materials contained many proteoglycans in them, which might have an association with the high intraocular pressure in this type of glaucoma.