MALDI-TOF-TOF Mass Spectrometer

MALDI-TOF-TOF质谱仪

• 批准号: 524610847
• 金额: --
• 依托单位: Martin-Luther-Universität Halle-Wittenberg
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/524610847?language=en
• 关键词: MALDI; TOF; Mass; Spectrometer

Modern polymer analysis requires high-resolution mass spectrometric techniques to analytically record the complexity of these molecules, both during synthesis and during their degradation. This applies, for example, to the sequence within polymer chains, the chain length (both in the case of synthetic and biological polymers), as well as the analysis of the chain structures, being of great importance in the context of the current SFB initiatives as well as the planned excellence initiative, where omplex structure/property relationships are to be analyzed. The MALDI-TOF-TOF MS applied for here replaces a device purchased 15 years ago, which has already exceeded its service life and is noticeable due to high repair/maintenance costs as well as reduced usability and already relatively low measuring accuracy. The newly purchased device has more modern technology, such as the TOF/TOF technology for the analysis of complex fragmentations and thus a more precise and detail-oriented structural analysis. MS analysis of polymers/macromolecules via MS spectroscopy, especially MALDI-TOF, is a standard methodology with great potential for expansion. It enables the determination of the exact molecular weight of high-molecular molecules, in resolution down to the isotope pattern, so that precise analysis of the composition, the chemical identity and the sequence of macromolecules is possible. This makes complex substance structures accessible both in terms of chemical structure and chemical-biological degradation, and the underlying mechanisms are understandable and therefore controllable. The device is directly integrated into the ongoing SFB TRR 102, the ongoing graduate school, as well as the ongoing third-party funded activities embedded in the group. The device is strategically central for the requested SFB initiatives as well as the SFB preliminary application SFB-TRR 382 as well as the planned application outline within the framework of the Federal Excellence Initiative. These initiatives are part of the planned excellence program that is being developed transregionally with the universities of Jena/Potsdam/Bayreuth. The aim of this program should be directed towards new aspects of the sustainability of polymers. In addition, research activities are to be located around the new Center of Sustainable Materials (CSME), wherein the MALDI-TOF-TOF will be integrated into the planned analytical unit.

现代聚合物分析需要高分辨率质谱技术来分析记录这些分子在合成过程中和降解过程中的复杂性。例如，这适用于聚合物链内的序列、链长（在合成和生物聚合物的情况下）以及链结构的分析，这在当前的 SFB 计划以及计划的卓越计划的背景下非常重要，其中需要分析复杂的结构/性能关系。这里申请的MALDI-TOF-TOF MS取代了15年前购买的设备，该设备已经超过其使用寿命，并且由于高昂的维修/维护成本以及可用性降低和测量精度已经相对较低而引人注目。新购买的设备具有更现代的技术，例如用于分析复杂碎片的TOF/TOF技术，从而可以进行更精确、更注重细节的结构分析。通过 MS 光谱（尤其是 MALDI-TOF）对聚合物/大分子进行 MS 分析是一种具有巨大扩展潜力的标准方法。它能够以同位素模式的分辨率测定高分子分子的精确分子量，从而可以精确分析大分子的组成、化学特性和序列。这使得复杂的物质结构在化学结构和化学生物降解方面都变得容易理解，并且潜在的机制是可以理解的，因此是可控的。该设备直接集成到正在进行的 SFB TRR 102、正在进行的研究生院以及该集团正在进行的第三方资助的活动中。该设备对于所请求的 SFB 计划以及 SFB 初步申请 SFB-TRR 382 以及联邦卓越计划框架内的计划应用大纲具有战略核心意义。这些举措是计划中的卓越计划的一部分，该计划正在与耶拿/波茨坦/拜罗伊特大学跨区域开发。该计划的目标应针对聚合物可持续性的新方面。此外，研究活动将围绕新的可持续材料中心（CSME）进行，其中 MALDI-TOF-TOF 将被整合到计划的分析单元中。