Change of autonomic nerve receptor in geriatric micturitional disturbance

老年排尿障碍自主神经受体的变化

• 批准号: 03670745
• 负责人: YASUDA Kosaku
• 金额: $ 1.15万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670745/
• 关键词: Alpha-stimulant; Beta-stimulant; Contractility; Urinary sphincter; Bladder neck contracture; Benign prostatic hypertrophy; Loss of energy; Hydraulic jump; 排尿エネルギー損失; 尿流動態検査; 尿道の収縮性; 排尿機能検査; 膀胱機能; 尿道機能; 前立腫肥大症; 膀胱頸部硬化症; 神経因性膀胱; 尿失禁; 排尿困難

Animal study : We reported that beta-stimulations enganced the contracility of fatigued urinry sphincter in female dogs. We found beta-stimulants also enhanced the comtracility of non-fatigued urinary sphincter this year. We ate now studying the effects of these drugs on the fast- and slow- contracting fibers of the urinary sphincter pespectively by the means of the ATP-ase staining.Clinical study : The energy loss in several portions of the urethra was higher at the external urinary sphincter (EUS) in volunteers and at the bladder neck (BN) in blodder neck contractuer (BNC) patients by the pressure/flow study using multi-transducer catheter. The results guggest that the hydraulic jump occurs at the EUS in volunteers an at the BN in BNC patients. The voiding energy at the bulbous urethra, which is located at the distal portion of the urethra ie in the BN in BNC patients. This year we srudied the voiding energy loss in benign prostatic hypertrophy (BPH) patients. In BPH patients like volunteers, the energy loss was highest at the EUS.The energy at the bulbous urethra was lower in NPH patients, the BN, prostatic urethra and the EUS make one strictural protion in the urethra and the hydraulic jump occrs at this point. alpha-blockers decreased the energy loss both in BNC and BPH patients.

动物研究：我们报道了β-刺激促进了雌性狗疲劳性尿液括约肌的不孕症。我们发现，今年，β-兴奋剂还可以增强非疲劳尿括约肌的收缩能力。临床研究：通过多探头导尿管压力/流量研究，志愿者的尿外括约肌(EUS)和膀胱颈(BNC)患者的部分尿路能量损失较高。结果推测，BNC患者的水跃发生在EUS和BNC患者的BN。BNC患者球状尿道处的排尿能量，位于BN的远端。今年我们研究了良性前列腺增生症(BPH)患者的排尿能量损失。良性前列腺增生症(BPH)患者的能量损失以EUS最高，NPH患者的球部尿路能量较低，BN、前列腺管和EUS在此点形成一个狭窄的尿路和水跃现象。α-受体阻滞剂减少了BNC和BPH患者的能量损失。

项目成果

K.Yamanishi et al.: "Lower urinary tract dysfunction in the anterior spinal artery syndrome" J Urol. 150. 1182-1184 (1993)

K.Yamanishi 等人：“脊髓前动脉综合征中的下尿路功能障碍”J Urol。

K.Yasuda et al: Management of pediatric out patient. Human T.Y.Co. Tokyo, 271 (1992)

K.Yasuda 等：儿科门诊患者的管理。

安田耕作, 垣添忠生,岡田裕作編集: "アトラス尿路変向術" 南江堂, 170 (1993)

安田耕作、柿添忠雄、冈田佑作编：“Atlas 尿路改道技术” Nankodo，170 (1993)

R.Sakakibara: "Micturitional disturbance in radiation myelopathy" J Spinal Disord. 6. 402-405 (1993)

R.Sakakibara：“放射性脊髓病中的排尿障碍”J Spinal Disord。

R.Sakakibara et al.: "Micturitional disturbance in radiation myelopathy" J Spinal Disord. 6. 402-405 (1993)

R.Sakakibara 等人：“放射性脊髓病中的排尿障碍”J Spinal Disord。