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APPLICATION OF PEN SHEET TO ARTIFICIAL SKIN AND MANUFACTURING OF CONTINUOUS PAPER-MAKING MACHINE

笔纸在人造皮肤上的应用及连续造纸机的制造

基本信息

批准号：
03555187
负责人：
TAKAI Mitsuo
金额：
$ 3.46万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1992
项目状态：
已结题

项目摘要

High resolution ^<13>C NMR spectra of alpha-chitin and beta-chitin in solid state can be distinguished from each other as well as the x-ray patterns or IR spectra. alpha-Chitin from crab or shrimp shell is known to be slightly soluble in general organic solvents and to have poor reactivity due to its rigid crystalline structure. beta-Chitin, on the other hand, from squid bone of Loligo pen, easily forms slurry when it was ground with water. This is responsible for the loose crystalline structure and the high hydrophilicity of Loligo pen chitin. Therefore it is much easier to prepare the paper sheet from beta-chitin than alpha-chitin without binder. Direct sheet preparation from Loligo pen gel is economically of greater advantage than nonwoven sheet from crab shell. The hand-made chitin paper from Loligo pen shows a high bursting factor of 7.4 and breaking length of 6.9 Km, compared with those of alpha-chitin from crab shell, 1.0 and 3.0 Km. The Loligo pen paper is obviously softer than that from crab shell as to rigidity or stiffness calculated from Young modulus. Furthermore the higher permeability of moisture together with water regain, a strong affinity for blood protein such as fibrinogen, albumin or gamma-globulin, and slow biodegradation by lysozyme were observed. Thus the pen sheet seems to be more suitable for temporarily artificial skin.In this report, the direct preparation of chitin sheet from mechanically beated loligo pen chitin was investigated. A continuous paper-making machine for the chitin was designed in bench scale and constructed in our Machine Shop. Paper of 30m long and 80mm wide can be prepared by the machine at the speed of 0.5m/min.

α<13>-甲壳素和β-甲壳素在固态下的高分辨率13 C NMR谱可以彼此区分，以及X射线图案或IR谱。已知来自蟹壳或虾壳的α-甲壳素微溶于一般有机溶剂，并且由于其刚性晶体结构而具有差的反应性。另一方面，来自Loligo pen的鱿鱼骨的β-几丁质在用水研磨时容易形成浆液。这是Loligo pen几丁质的松散晶体结构和高亲水性的原因。因此，在没有粘合剂的情况下，由β-甲壳质比由α-甲壳质制备纸张容易得多。从Loligo笔凝胶直接制备片材在经济上比从蟹壳制备非织造片材具有更大的优势。由Loligo笔手工制备的甲壳素纸的耐破因子为7.4，断裂长度为6.9 Km，而蟹壳α-甲壳素纸的耐破因子为1.0和3.0 Km。Loligo笔纸的硬度或由杨氏模量计算的刚度明显比蟹壳笔纸软。此外，还观察到较高的透湿性和回潮率，对血蛋白如纤维蛋白原、白蛋白或γ-球蛋白的强亲和力，以及溶菌酶的缓慢生物降解。本研究采用机械打浆法直接将Loligo pen甲壳素制备成甲壳素薄片。设计了一台甲壳素连续造纸机，并在我厂机械车间进行了试制。该机可抄出长30米、宽80毫米的纸张，速度为0.5米/分。