Coordination Funds

协调基金

• 批准号: 525003267
• 负责人: Professor Dr.-Ing. Kai Sundmacher
• 金额: --
• 依托单位: Lehrstuhl für Systemverfahrenstechnik
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/525003267?language=en
• 关键词: Coordination; Funds

Fine chemicals are very important as raw materials for the production of active pharmaceutical ingredients, polymers, cosmetics and detergent additives. Designing and operating an efficient and sustainable process in accordance with green chemistry principles, i.e. close to zero waste, for the production of a high-value fine chemical is a very demanding task. It involves several challenges: 1) identification of a multi-step chemical transformation path based on highly active, selective and stable catalysts for each step, 2) selection of suitable molecular building blocks to make the final target product, 3) selection of environmentally friendly solvents for all reaction and separation steps, 4) elucidation of the underlying reaction mechanisms and kinetics as a prerequisite for optimal reactor design and operation, 5) identification of efficient separation strategies for catalysts, solvents, unconverted reactants and by-products, 6) establishment of powerful purification methods for the final target product, 7) optimal design of an integrated reaction-separation system, and 8) optimal control of the overall production process to ensure stable operation. The central hypothesis of the proposed DFG Research Unit is that decisions on catalysts, solvents, additives, separation materials, devices and process operating conditions should be included in an integrated design methodology, supporting the simultaneous consideration of all essential variables available on the molecular level, phase level, process unit level and plant level. Thereby one can identify novel fine chemicals’ production processes that feature high productivity, high product quality and low waste. The suggested integrated design methodology will be developed and used for the design and operation of production processes for the multi-step catalytic synthesis of two pharmaceutically or biologically active examples of substance classes: a) homophenylalanine-based compounds, and b) long alkyl chain amino acids and amino alcohols. The chosen research approach requires close interdisciplinary cooperation between experts from the fields of catalysis, technical chemistry, chemical engineering and process systems engineering. Against this background, a team of scientists from Rostock (Prof. Matthias Beller, Prof. Udo Kragl, Dr. Christoph Kubis) and Magdeburg (Prof. Achim Kienle, Prof. Nora Kulak, Prof. Jan von Langermann, Prof. Heike Lorenz, Prof. Andreas Seidel-Morgenstern, Prof. Kai Sundmacher) was formed, who contribute complementary core competencies to the DFG Research Unit.

精细化学品是生产活性药物成分、聚合物、化妆品和洗涤剂添加剂的重要原材料。根据绿色化学原理（即接近零废物）设计和操作高效且可持续的工艺以生产高价值的精细化学品是一项非常艰巨的任务。它涉及若干挑战：1）基于用于每一步骤的高活性、选择性和稳定的催化剂，鉴定多步骤化学转化途径，2）选择合适的分子结构单元以制备最终目标产物，3）选择用于所有反应和分离步骤的环境友好的溶剂，4）阐明作为最佳反应器设计和操作的先决条件的潜在反应机理和动力学，5）确定催化剂、溶剂、未转化的反应物和副产物的有效分离策略，6）建立最终目标产物的强大纯化方法，7）集成反应-分离系统的优化设计，以及8）整个生产过程的优化控制以确保稳定操作。拟议DFG研究单位的中心假设是，催化剂，溶剂，添加剂，分离材料，设备和工艺操作条件的决定应包括在一个综合的设计方法，支持同时考虑分子水平上的所有基本变量，相水平，工艺单元水平和工厂水平。由此可以确定具有高生产率、高产品质量和低浪费的新型精细化学品生产工艺。将开发所建议的综合设计方法，并将其用于两种药物或生物活性物质类别实例的多步催化合成的生产工艺的设计和操作：a）基于高苯丙氨酸的化合物，和B）长烷基链氨基酸和氨基醇。所选择的研究方法需要来自催化，技术化学，化学工程和过程系统工程领域的专家之间的密切跨学科合作。在此背景下，来自罗斯托克（Matthias Beller教授、Udo Kragl教授、Christoph Kubis博士）和马格德堡（Achim Kienle教授、诺拉Kulak教授、Jan von Langermann教授、Heike Lorenz教授、Andreas Seidel-Morgenstern教授、Kai Sundmacher教授）的科学家组成了一个团队，他们为DFG研究部门贡献了互补的核心能力。