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Comparative study of ATL and HTLV-I related disorders

ATL和HTLV-I相关疾病的比较研究

基本信息

批准号：
04042015
负责人：
TAKATSUKI Kiyoshi
金额：
$ 3.46万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04042015/
关键词：
HTLV-I ATL HAM TSP Uveitis Mexico Cuba Brazil HTLV-Iぶどう膜炎 HTLV-Iキャリア

项目摘要

Human T lymphotropic virus type I (HTLV-I) has been etiologically associated with a hematological malignancy termed adult T-cell leukemia (ATL) and a chronic neurological disease named HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-I infection is endemic in some areas of the world, for example, the southern part of Japan, the Caribbean basin. Many of the ATL patients studied in the USA, the UK, France, and the Netherlands originated from the Caribbean area.Antibodies against HTLV-I have been detected in 1.2 million people and more than 700 cases of ATL are diagnosed each year in Japan alone. However, in some areas of Central and South America many HAM/TSP patients are observed but not so many ATL patients. Clinical course, ATL subtype, frequencies of hypercalcemia and opportunistic infections, cell morphology, phenotypic profile, and response to treatment seem to be the same for ATL in Japanese, Caribbean, and African patients. One of the differences is in age at onset : the average age is lower for the Caribbean and African than for Japanese ATL patients. And there is a relative paucity of the chronic subtype in Caribbean countries as compared to Japanese cases, while the lymphoma type is more common in Jamaica than in Japan.The reasons for the differences recorded are not clear. Environmental and genetic influences may be significant in providing different cofactors affecting the manifestations of the disease.

人类嗜T淋巴病毒I型（HTLV-I）与一种称为成人T细胞白血病（ATL）的血液恶性肿瘤和一种称为HTLV-I相关脊髓病/热带痉挛性截瘫（HAM/TSP）的慢性神经系统疾病有病因上的联系。HTLV-I感染在世界某些地区流行，例如日本南部和加勒比盆地。在美国、英国、法国和荷兰研究的许多ATL患者来自加勒比海地区。针对HTLV-I的抗体已在120万人中检测到，仅在日本，每年就诊断出700多例ATL。然而，在中美洲和南美洲的一些地区，观察到许多HAM/TSP患者，但没有那么多ATL患者。临床病程、ATL亚型、高钙血症和机会性感染的频率、细胞形态、表型特征和对治疗的反应似乎在日本、加勒比和非洲的ATL患者中是相同的。其中一个差异是发病年龄：加勒比和非洲ATL患者的平均年龄低于日本ATL患者。与日本病例相比，加勒比国家的慢性亚型病例相对较少，而淋巴瘤类型在牙买加比日本更常见。所记录的差异的原因尚不清楚。环境和遗传影响在提供影响疾病表现的不同辅助因素方面可能是重要的。