A study of adult T cell leukemia

成人 T 细胞白血病的研究

• 批准号: 01044116
• 负责人: TAKATSUKI Kiyoshi
• 金额: $ 7.55万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01044116/
• 关键词: ATL; HTLV-I; HAM; TSP; Epidemiology; HTLV-II; HTLVーI; HTLVーIキャリア; HTLVーI variant; レトロウイルス; カリブ海

Human T lymphotropic virus type I (HTLV-I) is a retrovirus associated with adult T cel1 leukemia, HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) and possibly with other diseases. HTLV-I is transmitted via breast milk, sexual intercourse and through blood transmission. Seroepidemiological studies have been shown distinct geographic clusters of HTLV-I and its associated diseases in southwestern Japan, the Caribbean basin, the southeastern United States and central Africa. The prevalence and distribution of HTLV-I around the world is unknown because the laboratory procedures that have been used in most of the sera&&&& epidemiologic studies cannot distinguish between HTLV-I and-II.We have investigated the seroprevalence of HTLV-I in Mexico, Cuba, Thailand, United Kingdom, USA, Brazil and Papua New Guinea for 3 years. We got some interested seropidemiological results from each countries.1) Yucatan, Mexico : a low prevalence of HTLV-I/II intection among eight population groups (14 positive cases of 2.277)2) Cuba : Very low seroprevalence of HTLV-I/II in blood donors and in hematological and nonhematological patients (one positive and 5 indeterminate cases of 2.429)3) Thailand : Very low seroprevalence of HTLV-I/II in patients with malignancies (only one case out of 882)4) Brazil : high seroprevalence of HTLV-I/II in blood donors and hematological disorders (in Recife 0.8% in donors was positive, and we diagnosed 20 cases as adult T cell leukemia in 2 hospitals in Rio de Janeiro)

人类嗜T淋巴细胞病毒I型（HTLV-I）是一种逆转录病毒，与成人T细胞白血病、HTLV-I相关性脊髓病/热带痉挛性下肢轻瘫（HAM/TSP）以及可能与其他疾病相关。HTLV-I通过母乳、性交和血液传播。血清流行病学研究表明，HTLV-I及其相关疾病在日本西南部、加勒比海盆地、美国东南部和非洲中部存在明显的地理集群。HTLV-I在世界各地的流行和分布是未知的，因为已经在大多数血清和流行病学研究中使用的实验室程序不能区分HTLV-I和-II。我们已经调查了HTLV-I在墨西哥，古巴，泰国，英国，美国，巴西和巴布亚新几内亚的血清阳性率3年。我们从每个国家获得了一些有趣的血清学结果：1）墨西哥尤卡坦州：8个人群中HTLV-I/II感染率较低（14例阳性病例，2.277）2）古巴：献血者以及血液学和非血液学患者中HTLV-I/II的血清阳性率非常低（1例阳性和5例不确定病例，共2.429例）3）泰国：恶性肿瘤患者中HTLV-I/II的血清阳性率非常低（882例中只有一例）4）巴西：献血者和血液病患者中HTLV-I/II高血清阳性率（在累西腓，0.8%的供体呈阳性，我们在里约热内卢的2家医院诊断出20例成人T细胞白血病）

项目成果

R.A Gongora-Biachi,K.Takatsuki et al: "A low prevalence of HTLV-I/II infection among eight population groups from Merida Yucatan,Mexico" Journal of AIDS. 5. 104-106 (1992)

R.A Kongora-Biachi、K.Takatsuki 等人：“墨西哥梅里达尤卡坦半岛八个人群中 HTLV-I/II 感染率较低”《艾滋病杂志》。

P.Hernandez,K.Takatsuki,et al: "Very low seroprevalence of HTLV-I/II in Cuba:Antibodies in blood donors and in hemeatological and nonhematological patients" Vox.Sang. 61. 277-278 (1991)

P.Hernandez、K.Takatsuki 等人：“古巴 HTLV-I/II 的血清阳性率极低：献血者以及血液病和非血液病患者中的抗体”Vox.Sang。

P.Hernandez,K.Takatsuki et al.: "Very low seroprevalence of HTLV-I/II in Cuba:Antibodies in blood donors and in hematological and non hematological patients" Vox Sang. 61. 277-278 (1991)

P.Hernandez、K.Takatsuki 等人：“古巴 HTLV-I/II 的血清阳性率极低：献血者以及血液病和非血液病患者中的抗体”Vox Sang。

Washitani Y,K.Yamaguchi K.Takatsuki et al.: "Serological discrimination between HTLV-I and HTLV-II antibodies by ELISA using synthetic peptides as antigens" Int.J.Cancer. 49. 173-177 (1991)

Washitani Y,K.Yamaguchi K.Takatsuki 等人：“使用合成肽作为抗原，通过 ELISA 区分 HTLV-I 和 HTLV-II 抗体”Int.J.Cancer。

Y. Washitani, K. Yamaguchi, K. Takatsuki, et al: "Serological discrimination between HTLV-I and HTLV-II antibodies by ELISA using synthetic peptides as antigens" Int. J. Cancer. 49. 173-177 (1991)

Y. Washitani、K. Yamaguchi、K. Takatsuki 等人：“使用合成肽作为抗原，通过 ELISA 方法区分 HTLV-I 和 HTLV-II 抗体” Int。