Japan-China Study on Genetic Factors for CVD Prevention

中日心血管疾病预防遗传因素研究

• 批准号: 04044119
• 负责人: YAMORI Yukio
• 金额: $ 4.99万
• 依托单位: Kyoto University (1993-1994)Shimane Medical University (1992)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04044119/
• 关键词: Hakka; Hypertension; Genetic factor for hypertension; Nutrition; 循環器疾患; 遺伝; 予知・予防; ネパール; 血圧; コレステロール

We conducted nutritional and cardiovascular disease (CVD) epidemiological study on genetic factors for CVD prediction and prevention in Meixian, Guangdong, People's Republic of China. Fifty-five males (M) and 65 females (F) at the age of 40-60 were recruited (78% response rate) from Hakka people living around Meixian area for height and body weight measurement, blood pressure (BP) , 24hour urine (24hu) collection, blood test and medical interview on diet and medical history. They showed low body mass index (Kg/m^2) (M : 20.9<plus-minus>3.2, F : 21.5<plus-minus>2.6, mean<plus-minus>SD) and relatively low systolic BP (SBP) (M : 127.7<plus-minus>19.0, F : 122.6<plus-minus>20.4 mmHg) and diastolic BP (DBP) (M : 75.5<plus-minus>12.0, F : 70.3<plus-minus>11.6) having low rate of hypertensive (HT) patient who showed SBP <greater than or equal>160 and/or DBP <greater than or equal>95 and/or on anti-HT medication. 24hu sodium (Na) excretion (M : 158.5<plus-minus>68.3 mEq/day, F : 150.0<plus-minus>63.2) was relatively low level among Chinese populations. Potassium (K) (M : 38.0<plus-minus>20.7 mEq/day, F : 37.5<plus-minus>15.5) was not high enough, so their Na/K ratio (M : 4.7<plus-minus>2.0, F : 4.4<plus-minus>1.9) did not reach ideal level. 24hu taurine (TAU) excretion (M : 1437.7<plus-minus>1160.4 mEq/day, F : 1721.3<plus-minus>1077.1) , which has beneficial effects against HT and atherosclerotic diseases, was relatively high level among Chinese populations, but less than Japanese populations taking a lot of sea-foods. TAU could be derived from liver and kidney of animals (pig, cow, etc.) , as well as sea-food protein, people in Meixian often intake pig's internal organs. We picked up 10 families from Hakka people for HT genes analysis, 3 of them had serious HT

我们在中华人民共和国广东省梅县进行了营养与心血管疾病（CVD）流行病学研究，探讨CVD预测和预防的遗传因素。从梅县周边地区的客家人中招募了55名男性（M）和65名女性（F）（响应率78%），年龄在40-60岁之间，进行身高和体重测量、血压（BP）、24小时尿液（24 hu）采集、血液检查以及饮食和病史的医学询问。他们表现出较低的体重指数（Kg/m^2）（M：20.9 <plus-minus>± 3.2，F：21.5 <plus-minus>± 2.6，平均<plus-minus>SD）和相对较低的收缩压（SBP）（M：127.7 <plus-minus>± 19.0，F：122.6 <plus-minus>± 20.4 mmHg）和舒张压（DBP）（M：75.5 <plus-minus>± 12.0，F：70.3 <plus-minus>± 11.6），显示SBP <greater than or equal>160和/或DBP <greater than or equal>95和/或服用抗HT药物的高血压（HT）患者比例较低。24 hu钠（Na）排泄量（男：158.5 <plus-minus>± 68.3mEq/d，女：150.0 ± <plus-minus>63.2mEq/d）在中国人群中处于较低水平。钾（K）（M：38.0 <plus-minus>~ 20.7 mEq/d，F：37.5 <plus-minus>~ 15.5）水平不高，Na/K比值（M：4.7 ~ <plus-minus>2.0，F：4.4 ~ <plus-minus>1.9）未达到理想水平。24 hu牛磺酸（TAU）排泄量（M：1437.7 <plus-minus>~ 1160.4mEq/d，F：1721.3 <plus-minus>~ 1077.1）在中国人群中相对较高，但低于食用大量海产品的日本人群，对HT和动脉粥样硬化性疾病具有有益作用。TAU可来源于动物（猪、牛等）的肝脏和肾脏。除了海产品蛋白质外，梅县人还经常食用猪内脏。我们从10个客家人家系中选取HT基因进行分析，其中3个家系有严重的HT