Use of receptor-type oncogene c-ergB-2 for the diagnosis and treatment of human cancers
Use of receptor-type oncogene c-ergB-2 for the diagnosis and treatment of human cancers
批准号:
04557019
负责人:
MORI Shigeo
金额:
$10.37万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
财政年份:
1992
资助国家:
日本
项目状态:
已结题
起止时间:
1992 至 1994
中文摘要
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英文摘要
a. We established the method for quantitation of serum c-ErbB-2 protein levels with the introduction of ELISA and RIA.The outcome was shown to be stable and reliable. This system is now under evaluation for clinical use at the Ministry of Welfare.b. The following new findings were obtained concerning the c-erbB-2 gene, product, and related genes.i The Estradiol was shown to work as a ligant for the c-ErbB-2 protein.ii New receptor-type tyrosine kinase brt was found.iii A new oncogenic chimeric protein tyrosine kinase P80 was identified.iv The promoter site of c-erbB-2 gene was revealed.v Fgr, a src-type tyrosine kinase was shown to associate with IgG Fc receptor II.
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Inoue K: "WTI as a new prognostic factor and a new marker for The detection of minimal residual disease in acute leukemia." BLood. 84. 3071-3079 (1994)
Inoue K:“WTI 作为一种新的预后因素和检测急性白血病微小残留病的新标志物。”
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Jiro Fujimoto: "brt,a mouse gene encoding a novel receptor-type protein-tyrosine kinase,is preferentia Ug expressed in the brain." Oncogene. 9. 693-698 (1994)
Jiro Fujimoto:“brt,一种编码新型受体型蛋白酪氨酸激酶的小鼠基因,优先在大脑中表达Ug。”
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Shiota M.: "Hyperphosphorylation of a novel 80-kDa protein-tyrosine kinase in a human Ki-1 lymphomacell line,AMS3." Oncogene. 9. 1567-1574 (1994)
Shiota M.:“人类 Ki-1 淋巴瘤细胞系 AMS3 中新型 80 kDa 蛋白酪氨酸激酶的过度磷酸化。”
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Sugano K: "Demonstration of ErbB-2 protein excreted from milk by RIA." Gan-no-rinsho. 40. 921-930 (1994)
Sugano K:“通过 RIA 演示从牛奶中排出 ErbB-2 蛋白。”
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Nagata K,Kohda D,Hatanaka H,Ichikawa S,Matsuda S,Yamamoto T,Suzuki A,Inagaki F: "Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180 erbB-4" EMBO. 13. 3517-3523 (1994)
Nagata K、Kohda D、Hatanaka H、Ichikawa S、Matsuda S、Yamamoto T、Suzuki A、Inagaki F:“heregulin-α 的表皮生长因子样结构域的溶液结构,p180 erbB-4 的配体”EMBO。
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共 32 条
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Subtyping of diffuse large B cell lymphomas by molecules highly expressed on germinal center B cells.
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Development of new methods in diagnosis and treatment of tumors by the targeting of chimeric protein
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Remodeling of the classification of malignant lymphomas occurring among Japanese based on molecular abnormality
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The pathology of Ki-1 lymphoma
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Analysis of dorsal light tilt reaction and cerebellar activities in carp during aircraft parabolic-flight weightlessness
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海外基金