The pathology of Ki-1 lymphoma

Ki-1淋巴瘤是人类恶性淋巴瘤的一个亚型，约占2- 7%。在Ki-1淋巴瘤发病机制尚不清楚的情况下，我们发现一种新的嵌合蛋白p80在40%的Ki-1淋巴瘤中高表达，该蛋白由2号染色体上的ALK基因和5号染色体上的核磷蛋白基因组成。在本研究中，我们发现p80在一定的时间点以正向（交换）方式影响正常的信号转导通路，导致宿主细胞的高度增殖。特别的是，我们与国外研究小组合作，发现p80在Ki-1淋巴瘤中高表达，而在病理组织学相似的霍奇金病中无表达。我们的结论是，Ki-1淋巴瘤表达p80是一个独特的疾病实体的表型以及发病机制

Ki-1 lymphoma is a subtyper of human malignant lymphoma comprizing its 2-7%. Whlee the pathogenetic mechanism of Ki-1 lymphoma remained unknown, we noted a novel chimeRic protein p80, composed partly ALK gene on chromosome 2 and partly of nucleophosmin gene on chromosome 5, is highly expressed on 40% of Ki-1 lymphomas. IN the present study, we formed that p80 affects normal signal transduction passway on positive (swutch-on) way at a certain points causing high proliferation of host cells. Also formd the ALK gene to be highly expressed in murine brain, suggesting its normal role on nerve function.Peculiarly, with the co-operation of oversea groups, we found that p80 is expressed highly in Ki-1 lymphomas but not in Hodgkin's desease that share similar histopathology. It is our conclusion that Ki-1 lymphoma expressing p80 is a unique disease entity in phenotype as well as pathogenesis