The pathology of Ki-1 lymphoma

Ki-1淋巴瘤的病理学

• 批准号: 07457048
• 负责人: MORI Shigeo
• 金额: $ 3.9万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457048/
• 关键词: Malignant lymphoma; Anaplastic large cell lymphoma; chimerie gene; Translocation of chromosome; Hodgkin's disease; ホジキン病; CD30; キメラ蛋白; 染色体; 転座

Ki-1 lymphoma is a subtyper of human malignant lymphoma comprizing its 2-7%. Whlee the pathogenetic mechanism of Ki-1 lymphoma remained unknown, we noted a novel chimeRic protein p80, composed partly ALK gene on chromosome 2 and partly of nucleophosmin gene on chromosome 5, is highly expressed on 40% of Ki-1 lymphomas. IN the present study, we formed that p80 affects normal signal transduction passway on positive (swutch-on) way at a certain points causing high proliferation of host cells. Also formd the ALK gene to be highly expressed in murine brain, suggesting its normal role on nerve function.Peculiarly, with the co-operation of oversea groups, we found that p80 is expressed highly in Ki-1 lymphomas but not in Hodgkin's desease that share similar histopathology. It is our conclusion that Ki-1 lymphoma expressing p80 is a unique disease entity in phenotype as well as pathogenesis

Ki-1淋巴瘤是人类恶性淋巴瘤的一个亚型，约占2- 7%。在Ki-1淋巴瘤发病机制尚不清楚的情况下，我们发现一种新的嵌合蛋白p80在40%的Ki-1淋巴瘤中高表达，该蛋白由2号染色体上的ALK基因和5号染色体上的核磷蛋白基因组成。在本研究中，我们发现p80在一定的时间点以正向（交换）方式影响正常的信号转导通路，导致宿主细胞的高度增殖。特别的是，我们与国外研究小组合作，发现p80在Ki-1淋巴瘤中高表达，而在病理组织学相似的霍奇金病中无表达。我们的结论是，Ki-1淋巴瘤表达p80是一个独特的疾病实体的表型以及发病机制

项目成果

Lamant,M.,Megetto,F.,Mori,S.and Delsol,G.: "High incidence of the t(2;5)(p23;q35)translocation in anaplastic large cell lymphoma and the lack of detection in Hodgkin's disease." Blood. 87. 284-291 (1996)

Lamant,M.、Megetto,F.、Mori,S. 和 Delsol,G.：“间变性大细胞淋巴瘤中 t(2;5)(p23;q35) 易位的发生率很高，而霍奇金病中缺乏检测

Shiota M and Mori S: "The clinicopathologic features of anaplastic large cell lymphomas expressing p80 (review)" Leukemia and Lymphoma. 23. 25-32 (1996)

Shiota M 和 Mori S：“表达 p80 的间变性大细胞淋巴瘤的临床病理特征（综述）”白血病和淋巴瘤。

Fujimoto J,Shiota M,Iwahara T,Seki N,Sato H,Mori S,Yamamoto T: "Characterization cell line with chromosomal translocation t (2 ; 5)" Proc Natl Acad Sci USA. 93. 4181-4186 (1996)

Fujimoto J、Shiota M、Iwahara T、Seki N、Sato H、Mori S、Yamamoto T：“染色体易位 t (2 ; 5) 的细胞系表征”Proc Natl Acad Sci USA。

Yee HT,Ponzoni M,Merson A,Mori S,Frizzera G,Inghirami G: "Molecular characterization of the t(2 ; 5)(p23 ; q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease." Blood. 87. 1081-1088 (1996)

Yee HT、Ponzoni M、Merson A、Mori S、Frizzera G、Inghirami G：“间变性大细胞淋巴瘤 (Ki-1) 和霍奇金病中 t(2 ; 5)(p23 ; q35) 易位的分子特征。”

Ichinohazama R,Endoh K,Mori S,Sawai T: "Thymic lymphoblastic lymphoma of committed natural killer precursor origin.A case report." Cancer. 77. 2592-603 (1996)

Ichinhazama R、Endoh K、Mori S、Sawai T：“自然杀伤前体起源的胸腺淋巴母细胞淋巴瘤。病例报告。”