Remodeling of the classification of malignant lymphomas occurring among Japanese based on molecular abnormality

基于分子异常重塑日本恶性淋巴瘤分类

基本信息

批准号：
08307003
负责人：
MORI Shigeo
金额：
$ 20.48万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08307003/
关键词：
malignant lymphoma Epstein Barr virus Human herpes virus 8 Hodgkin's disease Castleman's tumor 染色体病理分類分類 bcl6 p80

项目摘要

(1) Study on the pathogenesis of human malignant lymphomas :Malignant lymphomas has been classified traditionally on the basis of morphology, in 1980th, a new technology, the immunohistochemistry increased the accuracy of lymphoma classification. Thus, most of the standard classifications of lymphoma on this era are based on morphology and immunology. In 1990th, the pathogenesis of lymphoma cases began to be clarified gradually. Marked progress is noted in this field every year, while the whole aspects of lymphoma pathogenesis takes further years before the clarification. Present studies have added a little of new information on the pathogenesis of lymphomas, as are shown in publication lists.(2) Racio/geographical specificities of malignant lymphomas among Japanese :The existence of racio/geographical specificities of malignant lymphomas among Japanese has been noted. Present projects tried to clarify the molecular aspects of such specificities. Much heavier contribution of Epstein-Barr viruses among Japanese, the clarification of biological functions of new oncogenes that were found by our members, or the identification of HHV-8 infection among Japanese will be the typical example of this line of study.(3) Remodeling of lymphoma classification among Japanese :Together with the clarification of molecular mechanism, we collected Japanese lymphoma cases and started to classify them from new molecular information. So far we could collect over 3000 cases and are now analyzing them with molecular methods as well as immunophenotyping and morphology.

（1）研究人类恶性淋巴瘤的发病机理：传统上根据形态学对恶性淋巴瘤进行了分类，1980年代，一种新技术，一种新技术，免疫组织化学提高了淋巴瘤分类的准确性。因此，这个时代的淋巴瘤的大多数标准分类都是基于形态学和免疫学。在1990年代，淋巴瘤病例的发病机理开始逐渐澄清。每年在这一领域都有明显的进展，而淋巴瘤发病机理的整个方面需要详细介绍。目前的研究增加了有关淋巴瘤发病机理的一些新信息，如出版清单所示。（2）日本人中恶性淋巴瘤的种族/地理特异性：日本中恶性淋巴瘤的种族/地理特异性存在。目前的项目试图阐明这种特殊性的分子方面。 Much heavier contribution of Epstein-Barr viruses among Japanese, the clarification of biological functions of new oncogenes that were found by our members, or the identification of HHV-8 infection among Japanese will be the typical example of this line of study.(3) Remodeling of lymphoma classification among Japanese :Together with the clarification of molecular mechanism, we collected Japanese lymphoma cases and started to classify them from new molecular information.到目前为止，我们可以收集3000多个病例，现在正在使用分子方法以及免疫表型和形态进行分析。