Remodeling of the classification of malignant lymphomas occurring among Japanese based on molecular abnormality

基于分子异常重塑日本恶性淋巴瘤分类

• 批准号: 08307003
• 负责人: MORI Shigeo
• 金额: $ 20.48万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08307003/
• 关键词: malignant lymphoma; Epstein Barr virus; Human herpes virus 8; Hodgkin's disease; Castleman's tumor; 染色体; 病理分類; 分類; bcl6; p80

(1) Study on the pathogenesis of human malignant lymphomas :Malignant lymphomas has been classified traditionally on the basis of morphology, in 1980th, a new technology, the immunohistochemistry increased the accuracy of lymphoma classification. Thus, most of the standard classifications of lymphoma on this era are based on morphology and immunology. In 1990th, the pathogenesis of lymphoma cases began to be clarified gradually. Marked progress is noted in this field every year, while the whole aspects of lymphoma pathogenesis takes further years before the clarification. Present studies have added a little of new information on the pathogenesis of lymphomas, as are shown in publication lists.(2) Racio/geographical specificities of malignant lymphomas among Japanese :The existence of racio/geographical specificities of malignant lymphomas among Japanese has been noted. Present projects tried to clarify the molecular aspects of such specificities. Much heavier contribution of Epstein-Barr viruses among Japanese, the clarification of biological functions of new oncogenes that were found by our members, or the identification of HHV-8 infection among Japanese will be the typical example of this line of study.(3) Remodeling of lymphoma classification among Japanese :Together with the clarification of molecular mechanism, we collected Japanese lymphoma cases and started to classify them from new molecular information. So far we could collect over 3000 cases and are now analyzing them with molecular methods as well as immunophenotyping and morphology.

(1)人类恶性淋巴瘤发病机制的研究：恶性淋巴瘤传统上一直以形态学为基础进行分类，20世纪80年代新技术的出现，免疫组化提高了淋巴瘤分类的准确性。因此，这个时代淋巴瘤的大多数标准分类是基于形态学和免疫学。20世纪90年代，淋巴瘤的发病机制开始逐渐明确。在这一领域每年都有显著的进展，而淋巴瘤发病机制的整个方面需要进一步的澄清。目前的研究增加了一些新的信息，淋巴瘤的发病机制，如出版物列表中所示。(2)日本人恶性淋巴瘤的种族/地理特异性：已注意到日本人恶性淋巴瘤存在种族/地理特异性。目前的项目试图澄清这种特异性的分子方面。日本人中EB病毒的贡献要大得多，我们成员发现的新癌基因的生物学功能的澄清，或日本人中HHV-8感染的鉴定将是这一研究路线的典型例子。(3)日本淋巴瘤分类的重塑：在阐明分子机制的同时，我们收集了日本淋巴瘤病例，并开始根据新的分子信息对其进行分类。到目前为止，我们已经收集了3000多个病例，现在正在用分子方法以及免疫表型和形态学来分析它们。

项目成果

Yamochi T: "Adenovirus-mediated high expression of BCL-6 in CV-1 cells induces apoptotic cell death accompanied by down-regulation of BCL-2 and BCL-XL." Oncogene. (in press). (1999)

Yamochi T：“CV-1 细胞中腺病毒介导的 BCL-6 高表达可诱导细胞凋亡，并伴有 BCL-2 和 BCL-XL 的下调。”

Yamochi T.: "Adenovirus-mediated high expression of BCL-6 in CV-1 cells induces apoptotic cell death accompanied by down-regulation of BCL-2 and BLC-XL." Oncogene. 18. 487-494 (1999)

Yamochi T.：“CV-1 细胞中腺病毒介导的 BCL-6 高表达可诱导细胞凋亡，并伴有 BCL-2 和 BLC-XL 的下调。”

Yasunaga Y.: "Different patterns of p53 mutations in prostatic intraepithelial neoplasia and concurrent carcinoma : analysis of microdissected specimens." Lab Invest. 78(10). 1275-9 (1998)

Yasunaga Y.：“前列腺上皮内瘤变和并发癌中 p53 突变的不同模式：显微解剖标本的分析。”

Yumoto N.: "A particular characteristic of IgHcomplementarity-determining region 3 suggests autoreactive B-cell origin of primary gastric B-cell lymphomas." Lab Inv.78(3). 261-8 (1998)

Yumoto N.：“IgH 互补决定区 3 的一个特殊特征表明原发性胃 B 细胞淋巴瘤的自身反应性 B 细胞起源。”

Yamochi T,Kaneita Y,Akiyama T,Mori S,Moriyama M.: "Adenovirus-mediated high expression of BCL-6 in CV-1 cell sinduces apoptotic cell death accompanied by down-regulation of BCL2 and BCL-XL." Oncogene. 18. 487-494 (1999)

Yamochi T、Kaneita Y、Akiyama T、Mori S、Moriyama M.：“腺病毒介导的 CV-1 细胞中 BCL-6 的高表达会导致细胞凋亡，并伴有 BCL2 和 BCL-XL 的下调。”